Stereoselective preparation of functionalized tertiary P-chiral phosphine oxides by nucleophilic addition of lithiated tert-butylphenylphosphine oxide to carbonyl compounds.

被引：50
作者：
Haynes, RK
Lam, WWL
Yeung, LL
机构：
[1] Department of Chemistry, Hong Kong Univ. of Sci. and Technol., Kowloon, Clear Water Bay Road
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 27期
关键词：
D O I：
10.1016/0040-4039(96)00952-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Nucleophilic carbonyl and conjugate addition reactions of configurationally stable lithiated P-chiral tert-butylphenylphosphine oxide with aldehydes and alpha,beta-unsaturated carbonyl compounds occur in good yields with diastereoselectivities ranging from 33 to greater than or equal to 98%. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：4729 / 4732
页数：4
相关论文
共 17 条
12