Communicating health information and improving coordination with primary care (CHIIP): Rationale and design of a randomized cardiovascular health promotion trial for adult survivors of childhood cancer

被引：10

作者：

Chow, Eric J. ^{[1
,2
,3
]}

Baldwin, Laura-Mae ^{[4
]}

Hagen, Anna M. ^{[1
]}

Hudson, Melissa M. ^{[5
,6
]}

Gibson, Todd M. ^{[6
]}

Kochar, Komal ^{[6
]}

McDonald, Aaron ^{[6
]}

Nathan, Paul C. ^{[7
]}

Syrjala, Karen L. ^{[1
,2
]}

Taylor, Sarah L. ^{[1
]}

Tonorezos, Emily S. ^{[8
]}

Yasui, Yutaka ^{[6
]}

Armstrong, Gregory T. ^{[6
]}

Oeffinger, Kevin C. ^{[9
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Seattle, WA 98109 USA

[2] Fred Hutchinson Canc Res Ctr, Clin Res Div, Seattle, WA 98109 USA

[3] Univ Washington, Dept Pediat, Seattle, WA 98195 USA

[4] Univ Washington, Dept Family Med, Seattle, WA 98195 USA

[5] St Jude Childrens Res Hosp, Dept Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA

[6] St Jude Childrens Res Hosp, Dept Epidemiol & Canc Control, 332 N Lauderdale St, Memphis, TN 38105 USA

[7] Univ Toronto, Hosp Sick Children, Dept Pediat, Toronto, ON, Canada

[8] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA

[9] Duke Univ, Dept Med, Durham, NC USA

来源：

CONTEMPORARY CLINICAL TRIALS | 2020年 / 89卷

基金：

美国国家卫生研究院;

关键词：

Cancer survivor; Childhood cancer; Cardiovascular disease; Randomized clinical trial; Survivorship care plan; RISK-FACTORS; SCIENTIFIC STATEMENT; SELF-MANAGEMENT; MEDICAL-CARE; LIFE-STYLE; PARTICIPATION; PREVENTION; DISEASE; YOUNG; PREFERENCES;

D O I：

10.1016/j.cct.2019.105915

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: Long-term survival for children diagnosed with cancer exceeds 80%. Notably, premature cardiovascular disease has become the leading non-cancer cause of late mortality among these survivors. Methods/design: This randomized controlled trial (RCT; NCT03104543) focuses on adult participants in the Childhood Cancer Survivor Study identified as high risk for ischemic heart disease or heart failure due to their cancer treatment. Participants undergo a home-based evaluation of blood pressure and laboratory tests to determine the prevalence of undiagnosed and/or undertreated hypertension, dyslipidemia, and diabetes. Those with abnormal values are then enrolled in an RCT to test the efficacy of a 12-month personalized, remotely delivered survivorship care plan (SCP) intervention designed to reduce undertreatment of these three target conditions. The intervention approximates a clinical encounter and is based on chronic disease self-management strategies. Results: With a goal of 750, currently 342 out of 742 eligible participants approached have enrolled (46.1%). Initially, we randomized participants to different recruitment strategies, including shorter approach packets and a tiered consent, but did not find significant differences in participation rates (40.7% to 42.9%; p = .95). Subsequently, slightly greater participation was seen with larger upfront unconditional incentive checks ($50 vs. $25: 50.7% vs. 44.1%; p = .10). Overall, the financial impact of the $50 upfront incentive was cost neutral, and possibly cost-saving, vs. a $25 upfront incentive. Conclusion: The overall study will determine if a National Academy of Medicine-recommended SCP intervention can improve cardiovascular outcomes among long-term survivors of childhood cancer. Modifications to the recruitment strategy may improve participation rates over time.

引用

页数：8