The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency

被引:25
作者
Arora, Prerna [1 ,2 ]
Rocha, Cheila [1 ,2 ]
Kempf, Amy [1 ,2 ]
Nehlmeier, Inga [1 ]
Graichen, Luise [1 ,2 ]
Winkler, Martin S. [3 ]
Lier, Martin [3 ]
Schulz, Sebastian [4 ]
Jack, Hans-Martin [4 ]
Cossmann, Anne [5 ]
Stankov, Metodi V. [5 ]
Behrens, Georg M. N. [5 ]
Pohlmann, Stefan [1 ,2 ]
Hoffmann, Markus [1 ,2 ]
机构
[1] German Primate Ctr, Infect Biol Unit, Kellnerweg 4, D-37077 Gottingen, Germany
[2] Georg August Univ Gottingen, Fac Biol & Psychol, Wilhelmspl 1, D-37073 Gottingen, Germany
[3] Georg August Univ Gottingen, Univ Gottingen Med Ctr, Dept Anesthesiol, Robert Koch Str 40, D-37075 Gottingen, Germany
[4] Friedrich Alexander Univ Erlangen Nurnberg, Div Mol Immunol, Dept Internal Med 3, Gluckstr 6, D-91054 Erlangen, Germany
[5] Hannover Med Sch, Dept Rheumatol & Immunol, Carl Neuberg Str 1, D-30625 Hannover, Germany
关键词
D O I
10.1038/s41423-021-00779-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:2673 / 2675
页数:3
相关论文
共 10 条
[1]   Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination [J].
Barros-Martins, Joana ;
Hammerschmidt, Swantje, I ;
Cossmann, Anne ;
Odak, Ivan ;
Stankov, Metodi, V ;
Ramos, Gema Morillas ;
Dopfer-Jablonka, Alexandra ;
Heidemann, Annika ;
Ritter, Christiane ;
Friedrichsen, Michaela ;
Schultze-Florey, Christian ;
Ravens, Inga ;
Willenzon, Stefanie ;
Bubke, Anja ;
Ristenpart, Jasmin ;
Janssen, Anika ;
Ssebyatika, George ;
Bernhardt, Gunter ;
Muench, Jan ;
Hoffmann, Markus ;
Poehlmann, Stefan ;
Krey, Thomas ;
Bosnjak, Berislav ;
Foerster, Reinhold ;
Behrens, Georg M. N. .
NATURE MEDICINE, 2021, 27 (09) :1525-+
[2]   SARS-CoV-2 delta variant neutralisation after heterologous ChAdOx1-S/BNT162b2 vaccination [J].
Behrens, Georg M. N. ;
Cossmann, Anne ;
Stankov, Metodi V. ;
Nehlmeier, Inga ;
Kempf, Amy ;
Hoffmann, Markus ;
Poehlmann, Stefan .
LANCET, 2021, 398 (10305) :1041-1042
[3]  
COV-Lineages.org, LIN A 30
[4]   SARS-CoV-2 variants, spike mutations and immune escape [J].
Harvey, William T. ;
Carabelli, Alessandro M. ;
Jackson, Ben ;
Gupta, Ravindra K. ;
Thomson, Emma C. ;
Harrison, Ewan M. ;
Ludden, Catherine ;
Reeve, Richard ;
Rambaut, Andrew ;
Peacock, Sharon J. ;
Robertson, David L. .
NATURE REVIEWS MICROBIOLOGY, 2021, 19 (07) :409-424
[5]   SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies [J].
Hoffmann, Markus ;
Arora, Prerna ;
Gross, Rudiger ;
Seidel, Alina ;
Hornich, Bojan F. ;
Hahn, Alexander S. ;
Kruger, Nadine ;
Graichen, Luise ;
Hofmann-Winkler, Heike ;
Kempf, Amy ;
Winkler, Martin S. ;
Schulz, Sebastian ;
Jack, Hans-Martin ;
Jahrsdorfer, Bernd ;
Schrezenmeier, Hubert ;
Muller, Martin ;
Kleger, Alexander ;
Munch, Jan ;
Pohlmann, Stefan .
CELL, 2021, 184 (09) :2384-+
[6]   SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor [J].
Hoffmann, Markus ;
Kleine-Weber, Hannah ;
Schroeder, Simon ;
Krueger, Nadine ;
Herrler, Tanja ;
Erichsen, Sandra ;
Schiergens, Tobias S. ;
Herrler, Georg ;
Wu, Nai-Huei ;
Nitsche, Andreas ;
Mueller, Marcel A. ;
Drosten, Christian ;
Poehlmann, Stefan .
CELL, 2020, 181 (02) :271-+
[7]   Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant [J].
Madhi, S. A. ;
Baillie, V ;
Cutland, C. L. ;
Voysey, M. ;
Koen, A. L. ;
Fairlie, L. ;
Padayachee, S. D. ;
Dheda, K. ;
Barnabas, S. L. ;
Bhorat, Q. E. ;
Briner, C. ;
Kwatra, G. ;
Ahmed, K. ;
Aley, P. ;
Bhikha, S. ;
Bhiman, J. N. ;
Bhorat, A' E. ;
du Plessis, J. ;
Esmail, A. ;
Groenewald, M. ;
Horne, E. ;
Hwa, S-H ;
Jose, A. ;
Lambe, T. ;
Laubscher, M. ;
Malahleha, M. ;
Masenya, M. ;
Masilela, M. ;
McKenzie, S. ;
Molapo, K. ;
Moultrie, A. ;
Oelofse, S. ;
Patel, F. ;
Pillay, S. ;
Rhead, S. ;
Rodel, H. ;
Rossouw, L. ;
Taoushanis, C. ;
Tegally, H. ;
Thombrayil, A. ;
van Eck, S. ;
Wibmer, C. K. ;
Durham, N. M. ;
Kelly, E. J. ;
Villafana, T. L. ;
Gilbert, S. ;
Pollard, A. J. ;
de Oliveira, T. ;
Moore, P. L. ;
Sigal, A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (20) :1885-1898
[8]  
McCallum M, 2021, CELL, V184, P2332, DOI [10.1016/j.cell.2021.03.028, 10.1101/2021.01.14.426475]
[9]  
Schmidt Fabian, 2020, bioRxiv, DOI [10.1084/jem.20201181, 10.1101/2020.06.08.140871]
[10]  
Wibmer CK, 2021, NAT MED, V27, DOI [10.1038/s41591-021-01285-x, 10.1101/2021.01.18.427166]