Meta-Analysis of Anti-Muscarinic Receptor Type 3 Antibodies for the Diagnosis of Sjogren Syndrome

被引：9
作者：
Deng, Chuiwen
Hu, Chaojun
Chen, Si
Li, Jing
Wen, Xiaoting
Wu, Ziyan
Li, Yuan
Zhang, Fengchun
Li, Yongzhe [1 ]
机构：
[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing 100730, Peoples R China
来源：
PLOS ONE | 2015年 / 10卷 / 01期
基金：
中国国家自然科学基金;
关键词：
ACETYLCHOLINE-RECEPTOR; AUTOANTIBODIES; PEPTIDE;
D O I：
10.1371/journal.pone.0116744
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Purpose To conduct a meta-analysis to evaluate the diagnostic value of anti-muscarinic receptor type 3 (M3R) antibodies in Sjogren syndrome (SS). Methods Two databases, PUBMED and the Cochrane Library, were systematically searched. Approximately 2,000 participants from several studies were included in this research. STATA 11.2 software and Meta-DiSc 1.4 was used to conduct the meta-analysis. Results Eleven studies were included in the meta-analysis. The pooled DOR was 13.00 (95% CI, 6.00-26.00). The sensitivity was 0.43 (95% CI, 0.28-0.58) and the specificity was 0.95 (95%CI, 0.91-0.97). The LR+ and LR- were 7.90 (95% CI, 4.70-13.40), 0.61 (95% CI, 0.46-0.79), respectively. The AUC was 0.89 (95% CI, 0.86-0.92). Conclusion The anti-M3R antibody had high specificity but relatively low sensitivity for the diagnosis of SS.
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页数：9
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