Meta-Analysis of Anti-Muscarinic Receptor Type 3 Antibodies for the Diagnosis of Sjogren Syndrome

被引：9

作者：

Deng, Chuiwen

Hu, Chaojun

Chen, Si

Li, Jing

Wen, Xiaoting

Wu, Ziyan

Li, Yuan

Zhang, Fengchun

Li, Yongzhe ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing 100730, Peoples R China

来源：

PLOS ONE | 2015年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

ACETYLCHOLINE-RECEPTOR; AUTOANTIBODIES; PEPTIDE;

D O I：

10.1371/journal.pone.0116744

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Purpose To conduct a meta-analysis to evaluate the diagnostic value of anti-muscarinic receptor type 3 (M3R) antibodies in Sjogren syndrome (SS). Methods Two databases, PUBMED and the Cochrane Library, were systematically searched. Approximately 2,000 participants from several studies were included in this research. STATA 11.2 software and Meta-DiSc 1.4 was used to conduct the meta-analysis. Results Eleven studies were included in the meta-analysis. The pooled DOR was 13.00 (95% CI, 6.00-26.00). The sensitivity was 0.43 (95% CI, 0.28-0.58) and the specificity was 0.95 (95%CI, 0.91-0.97). The LR+ and LR- were 7.90 (95% CI, 4.70-13.40), 0.61 (95% CI, 0.46-0.79), respectively. The AUC was 0.89 (95% CI, 0.86-0.92). Conclusion The anti-M3R antibody had high specificity but relatively low sensitivity for the diagnosis of SS.

引用

页数：9

共 16 条

[1] Circulating antibodies against rat parotid gland M(3) muscarinic receptors in primary Sjogren's syndrome [J].

Bacman, S ;

SterinBorda, L ;

Camusso, JJ ;

Arana, R ;

Hubscher, O ;

Borda, E .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1996, 104 (03) :454-459

[2]

Bacman S, 2001, INVEST OPHTH VIS SCI, V42, P321

[3] Subgroups of Sjogren syndrome patients according to serological profiles [J].

Bournia, Vasiliki-Kalliopi ;

Vlachoyiannopoulos, Panayiotis G. .

JOURNAL OF AUTOIMMUNITY, 2012, 39 (1-2) :15-26

[4] Neuroimmune Interactions in Sjogren's Syndrome: Relationship of Exocrine Gland Dysfunction with Autoantibodies to Muscarinic Acetylcholine Receptor-3 and Mental Health Status Parameters [J].

Deak, Magdolna ;

Szvetnik, Attila ;

Balog, Attila ;

Sohar, Nicolette ;

Varga, Renata ;

Pokorny, Gyula ;

Toth, Gabor ;

Kiss, Maria ;

Kovacs, Laszlo .

NEUROIMMUNOMODULATION, 2013, 20 (02) :79-86

[5]

Eglen R. M., 2006, Autonomic & Autacoid Pharmacology, V26, P219, DOI 10.1111/j.1474-8673.2006.00368.x

[6]

He J, 2012, CLIN EXP RHEUMATOL, V30, P322

[7] Diagnostic significance of measuring antibodies to cyclic type 3 muscarinic acetylcholine receptor peptides in primary Sjogren's syndrome [J].

He, Jing ;

Guo, Jian-ping ;

Ding, Yan ;

Li, Ying-ni ;

Pan, Si-si ;

Liu, Yanying ;

Li, Zhan-guo .

RHEUMATOLOGY, 2011, 50 (05) :879-884

[8] The accuracy of the anti-α-fodrin antibody test for diagnosis of Sjogren's syndrome: A meta-analysis [J].

Hu, Qin ;

Wang, Ding ;

Chen, Weixian .

CLINICAL BIOCHEMISTRY, 2013, 46 (15) :1372-1376

[9] Clinical associations of autoantibodies to human muscarinic acetylcholine receptor 3213-228 in primary Sjogren's syndrome [J].

Kovács, L ;

Marczinovits, I ;

György, A ;

Tóth, GK ;

Dorgai, L ;

Pál, J ;

Molnár, J ;

Pokorny, G .

RHEUMATOLOGY, 2005, 44 (08) :1021-1025

[10] A peptide of human muscarinic acetylcholine receptor 3 is antigenic in primary Sjogren's syndrome [J].

Marczinovits, I ;

Kovács, L ;

György, A ;

Tóth, GK ;

Dorgai, L ;

Molnár, A ;

Pokorny, G .

JOURNAL OF AUTOIMMUNITY, 2005, 24 (01) :47-54

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