J-104,123, a novel and orally-active inhibitor of squalene synthase: Stereoselective synthesis and cholesterol lowering effects in dogs

被引：16
|
作者：
Iwasawa, Y
Shibata, J
Mitsuya, M
Masaki, H
Hayashi, M
Kanno, T
Sawasaki, Y
Hisaka, A
Kamei, T
Tomimoto, K
机构：
[1] Tsukuba Research Institute, Banyu Pharmaceutical Co. Ltd., Tsukuba 300-33
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 04期
关键词：
D O I：
10.1016/0960-894X(96)00033-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
J-104,123, a potent inhibitor of squalene synthase having monocarboxylic acid structure, was discovered by chemical modification of J-104,118. An oral dose of J-104,123 lowered serum cholesterol levels in dogs. J-104,123 was synthesized stereoselectively from methyl (R)-3-hydroxybutyrate.
引用
收藏
页码：463 / 466
页数：4
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