Assessment: Botulinum neurotoxin for the treatment of spasticity (an evidence-based review) - Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology

被引：252
作者：
Simpson, D. M. [1 ]
Gracies, J. -M. [2 ]
Graham, H. K.
Miyasaki, J. M. [3 ]
Naumann, M. [4 ]
Russman, B. [5 ]
Simpson, L. L. [6 ]
So, Y. [7 ]
机构：
[1] Mt Sinai Med Ctr, Dept Neurol, New York, NY 10029 USA
[2] CHU Henri Mondor, Dept Rehabil Med, F-94010 Creteil, France
[3] Toronto Western Hosp, Toronto, ON, Canada
[4] Klinikum Augsburg, Dept Neurol, Augsburg, Germany
[5] Shriners Hosp Children, Portland, OR 97201 USA
[6] Thomas Jefferson Univ, Jefferson Med Coll, Philadelphia, PA 19107 USA
[7] Stanford Univ, Stanford, CA 94305 USA
来源：
NEUROLOGY | 2008年 / 70卷 / 19期
关键词：
D O I：
10.1212/01.wnl.0000311391.00944.c4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective: To perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of adult and childhood spasticity. Methods: A literature search was performed including MEDLINE and Current Contents for therapeutic articles relevant to BoNT and spasticity. Authors reviewed, abstracted, and classified articles based on American Academy of Neurology criteria (ClassI-IV). Results: The highest quality literature available for the respective indications was as follows: adult spasticity (14 Class I studies); spastic equinus and adductor spasticity in pediatric cerebral palsy (six Class I studies). Recommendations: Botulinum neurotoxin should be offered as a treatment option for the treatment of spasticity in adults and children (Level A).
引用
收藏
页码：1691 / 1698
页数：8
相关论文
共 48 条
  • [1] Comparing botulinum toxin A with casting for treatment of dynamic equinus in children with cerebral palsy
    Ackman, JD
    Russman, BS
    Thomas, SS
    Buckon, CE
    Sussman, MD
    Masso, P
    Sanders, J
    D'Astous, J
    D Aiona, M
    [J]. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2005, 47 (09) : 620 - 627
  • [2] Botulinum toxin treatment of spasticity in diplegic cerebral palsy: a randomized, double-blind, placebo-controlled, dose-ranging study
    Baker, R
    Jasinski, M
    Maciag-Tymecka, I
    Michalowska-Mrozek, J
    Bonikowski, M
    Carr, L
    MacLean, J
    Lin, JP
    Lynch, B
    Theologis, T
    Wendorff, J
    Eunson, P
    Cosgrove, A
    [J]. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2002, 44 (10) : 666 - 675
  • [3] A randomized, double-blind, placebo-controlled, dose-ranging study to compare the efficacy and safety of three doses of botulinum toxin type A (Dysport) with placebo in upper limb spasticity after stroke
    Bakheit, AMO
    Thilmann, AF
    Ward, AB
    Poewe, W
    Wissel, J
    Muller, J
    Benecke, R
    Collin, C
    Muller, F
    Ward, CD
    Neumann, C
    [J]. STROKE, 2000, 31 (10) : 2402 - 2406
  • [4] The beneficial antispasticity effect of botulinum toxin type A is maintained after repeated treatment cycles
    Bakheit, AMO
    Fedorova, NV
    Skoromets, AA
    Timerbaeva, SL
    Bhakta, BB
    Coxon, L
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2004, 75 (11) : 1558 - 1561
  • [5] A randomized, double-blind, placebo-controlled study of the efficacy and safety of botulinum toxin type A in upper limb spasticity in patients with stroke
    Bakheit, AMO
    Pittock, S
    Moore, AP
    Wurker, M
    Otto, S
    Erbguth, F
    Coxon, L
    [J]. EUROPEAN JOURNAL OF NEUROLOGY, 2001, 8 (06) : 559 - 565
  • [6] Analgesic effects of botulinum toxin A: a randomized, placebo-controlled clinical trial
    Barwood, S
    Baillieu, C
    Boyd, R
    Brereton, K
    Low, J
    Nattrass, G
    Graham, HK
    [J]. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2000, 42 (02) : 116 - 121
  • [7] Impact of botulinum toxin type A on disability and carer burden due to arm spasticity after stroke: a randomised double blind placebo controlled trial
    Bhakta, BB
    Cozens, JA
    Chamberlain, MA
    Bamford, JM
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2000, 69 (02) : 217 - 221
  • [8] Botulinum toxin with and without casting in ambulant children with spastic diplegia: a clinical and functional assessment
    Bottos, M
    Benedetti, MG
    Salucci, P
    Gasparroni, V
    Giannini, S
    [J]. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2003, 45 (11) : 758 - 762
  • [9] Botulinum toxin type B in upper-limb poststroke spasticity: A double-blind, placebo-controlled trial
    Brashear, A
    McAfee, AL
    Kuhn, ER
    Fyffe, J
    [J]. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 2004, 85 (05): : 705 - 709
  • [10] Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after a stroke
    Brashear, A
    Gordon, MF
    Elovic, E
    Kassicieh, VD
    Marciniak, C
    Lee, CH
    Jenkins, S
    Turkel, C
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (06) : 395 - 400
12345