Acceleration of Emergence of Bacterial Antibiotic Resistance in Connected Microenvironments

被引：413

作者：

Zhang, Qiucen ^{[1
]}

Lambert, Guillaume ^{[1
]}

Liao, David ^{[2
]}

Kim, Hyunsung ^{[3
]}

Robin, Kristelle ^{[4
]}

Tung, Chih-kuan ^{[5
]}

Pourmand, Nader ^{[3
]}

Austin, Robert H. ^{[1
,4
]}

机构：

[1] Princeton Univ, Dept Phys, Princeton, NJ 08544 USA

[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[3] Univ Calif Santa Cruz, Santa Cruz Genome Sequencing Ctr, Santa Cruz, CA 95064 USA

[4] Hong Kong Univ Sci & Technol, Inst Adv Study, Kowloon, Hong Kong, Peoples R China

[5] Univ Pittsburgh, Dept Phys, Pittsburgh, PA 15260 USA

来源：

SCIENCE | 2011年 / 333卷 / 6050期

关键词：

ESCHERICHIA-COLI; FLUOROQUINOLONE RESISTANCE; EVOLUTION; INFECTIONS; MUTATION;

D O I：

10.1126/science.1208747

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The emergence of bacterial antibiotic resistance is a growing problem, yet the variables that influence the rate of emergence of resistance are not well understood. In a microfluidic device designed to mimic naturally occurring bacterial niches, resistance of Escherichia coli to the antibiotic ciprofloxacin developed within 10 hours. Resistance emerged with as few as 100 bacteria in the initial inoculation. Whole-genome sequencing of the resistant organisms revealed that four functional single-nucleotide polymorphisms attained fixation. Knowledge about the rapid emergence of antibiotic resistance in the heterogeneous conditions within the mammalian body may be helpful in understanding the emergence of drug resistance during cancer chemotherapy.

引用

页码：1764 / 1767

页数：4

共 23 条

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