Plasma atrial natriuretic peptide in fetuses with cardiac disease

被引：1
作者：
Bartha, JL
Penney, MD
Soothill, PW
机构：
[1] Univ Bristol, St Michaels Hosp, Dept Obstet & Gynecol, Fetal Med Res Unit, Bristol, Avon, England
[2] Royal Gwent Hosp, Dept Chem Pathol, Newport, Gwent, Wales
来源：
FETAL DIAGNOSIS AND THERAPY | 2005年 / 20卷 / 05期
关键词：
atrial natriuretic peptide; polyhydramnios; cardiac disease in fetuses; fetal heart disease;
D O I：
10.1159/000086825
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective:To investigate atrial natriuretic peptide (ANP) levels in fetuses with cardiac defects and to evaluate the relationships between plasma ANP levels and the presence of polyhydramnios. Methods: Plasma ANP levels were measured by radioimmunoassay in 27 fetuses with cardiac abnormalities and in 14 normal healthy fetuses. Results: Fetal plasma ANP levels were similar in the two studied groups (p = 0.18) but they were significantly higher in a subset of cases with cardiac disease and polyhydramnios (n = 7) than in those with cardiac disease and normal amniotic fluid (n = 20; p = 0.036) and controls (p = 0.01). Conclusion: Polyhydramnios in fetuses with heart conditions might be explained by increased fetal diuresis secondary to increased ANP production. Copyright (c) 2005 S. Karger AG, Basel.
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页码：426 / 430
页数：5
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