Organocatalytic asymmetric direct Michael addition of aromatic ketones to alkylidenemalononitriles

被引：31
|
作者：
Yue, Lei [1 ]
Du, Wei [1 ]
Liu, Yan-Kal [1 ]
Chen, Ying-Chun [1 ,2 ]
机构：
[1] Sichuan Univ, W China Sch Pharm, Educ Minist, Key Lab Drug Targeting, Chengdu 610041, Peoples R China
[2] Sichuan Univ, W China Sch Pharm, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 24期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.tetlet.2008.04.069
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The asymmetric direct Michael addition of aromatic ketones to highly active alkylidenemalononitriles was investigated by employing a chiral primary amine 9-amino-9-deoxyepicinchonine. In general modest to good enantioselectivities (71-84% ee) could be obtained in acceptable isolated yields (48-85%) for an array of substrates. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3881 / 3884
页数：4
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