A simple and green procedure for the conjugate addition of thiols to conjugated alkenes employing polyethylene glycol (PEG) as an efficient recyclable medium

被引：64

作者：

Kamal, A ^{[1
]}

Reddy, DR ^{[1
]}

Rajendar ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 46期

关键词：

conjugate addition; Thiols; conjugated alkenes; polyethylene glycol;

D O I：

10.1016/j.tetlet.2005.09.082

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polyethylene glycol (PEG) is found to be an inexpensive, nontoxic, environmentally friendly reaction medium for the conjugate addition of thiols to conjugated alkenes to afford the corresponding adducts in excellent yields under mild and neutral conditions. Products of undesirable side reactions resulting from polymerization are not observed. The use of PEG avoids the use of either acid or base catalysts for this conversion and moreover PEG can be recovered and reused. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：7951 / 7953

页数：3

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