Reliability and validity of the Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire in dyspepsia:: A six-country study

被引:266
作者
Kulich, Karoly R. [1 ]
Madisch, Ahmed [2 ]
Pacini, Franco [3 ]
Pique, Jose M. [4 ]
Regula, Jaroslaw [5 ]
Van Rensburg, Christo J. [6 ]
Ujszaszy, Laszlo [7 ]
Carlsson, Jonas [1 ]
Halling, Katarina [1 ]
Wiklund, Ingela K. [1 ]
机构
[1] AstraZeneca R&D, S-43186 Molndal, Sweden
[2] Tech Univ Hosp, Dept Med 1, D-01307 Dresden, Germany
[3] Azienda Osped Careggi, UO Gatroenterol & Endoscopia Digest, I-50139 Florence, Italy
[4] Hosp Clin Barcelona, Serv Gastroenterol, Barcelona 08036, Spain
[5] Ctr Onkol, Klin Gastroenterol CMKP, PL-02781 Warsaw, Poland
[6] Tygerberg Hosp, Gastroenterol Unit, ZA-7505 Cape Town, South Africa
[7] Semmelweis Hosp, H-3501 Miskolc, Hungary
关键词
D O I
10.1186/1477-7525-6-12
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Background: Symptoms of dyspepsia significantly disrupt patients' lives and reliable methods of assessing symptom status are important for patient management. The aim of the current study was to document the psychometric characteristics of the Gastrointestinal Symptom Rating Scale (GSRS) and the Quality of Life in Reflux and Dyspepsia questionnaire (QOLRAD) in Afrikaans, German, Hungarian, Italian, Polish and Spanish patients with dyspepsia. Methods: 853 patients with symptoms of dyspepsia completed the GSRS, the QOLRAD, the 36-item Short-Form Health Survey (SF-36) and the Hospital Anxiety and Depression scale. Results: The internal consistency reliability of the GSRS was 0.43-0.87 and of the QOLRAD 0.79-0.95. Test-retest reliability of the GSRS was 0.36-0.75 and of the QOLRAD 0.41-0.82. GSRS Abdominal pain domain correlated significantly with all QOLRAD domains in most language versions, and with SF-36 Bodily pain in all versions. QOLRAD domains correlated significantly with the majority of SF-36 domains in most versions. Both questionnaires were able to differentiate between patients whose health status differed according to symptom frequency and severity. Conclusion: The psychometric characteristics of the different language versions of the GSRS and QOLRAD were found to be good, with acceptable reliability and validity. The GSRS and QOLRAD were found to be useful for evaluating dyspeptic symptoms and their impact on patients' daily lives in multinational clinical trials.
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页数:12
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