MDMA (ecstasy) pharmacokinetics in a CYP2D6 poor metaboliser and in nine CYP2D6 extensive metabolisers

被引:37
作者
de la Torre, R
Farré, M
Mathúna, BO
Roset, PN
Pizarro, N
Segura, M
Torrens, M
Ortuño, J
Pujadas, M
Camí, J
机构
[1] IMIM, Pharmacol Unit, Barcelona 08003, Spain
[2] Univ Autonoma Barcelona, E-08193 Barcelona, Spain
[3] Univ Pompeu Fabra, Barcelona, Spain
[4] IAPS Hosp Mar, Barcelona, Spain
关键词
D O I
10.1007/s00228-005-0965-y
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
[No abstract available]
引用
收藏
页码:551 / 554
页数:4
相关论文
共 16 条
[1]   THE HYPERTHERMIC AND NEUROTOXIC EFFECTS OF ECSTASY (MDMA) AND 3,4-METHYLENEDIOXYAMPHETAMINE (MDA) IN THE DARK-AGOUTI (DA) RAT, A MODEL OF THE CYP2D6 POOR METABOLIZER PHENOTYPE [J].
COLADO, MI ;
WILLIAMS, JL ;
GREEN, AR .
BRITISH JOURNAL OF PHARMACOLOGY, 1995, 115 (07) :1281-1289
[2]   Human pharmacology of MDMA -: Pharmacokinetics, metabolism, and disposition [J].
de la Torre, R ;
Farré, M ;
Roset, PN ;
Pizarro, N ;
Abanades, S ;
Segura, M ;
Segura, J ;
Camí, J .
THERAPEUTIC DRUG MONITORING, 2004, 26 (02) :137-144
[3]   Repeated doses administration of MDMA in humans:: pharmacological effects and pharmacokinetics [J].
Farré, M ;
de la Torre, R ;
Mathúna, BO ;
Roset, PN ;
Peiró, AM ;
Torrens, M ;
Ortuño, J ;
Pujadas, M ;
Camí, J .
PSYCHOPHARMACOLOGY, 2004, 173 (3-4) :364-375
[4]   The effect of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and its metabolites on neurohypophysial hormone release from the isolated rat hypothalamus [J].
Forsling, ML ;
Fallon, JK ;
Shah, D ;
Tilbrook, GS ;
Cowan, DA ;
Kicman, AT ;
Hutt, AJ .
BRITISH JOURNAL OF PHARMACOLOGY, 2002, 135 (03) :649-656
[5]   Neuroendocrine abnormalities in recreational ecstasy (MDMA) users: Is it ecstasy or cannabis? [J].
Gouzoulis-Mayfrank, E ;
Becker, S ;
Pelz, S ;
Tuchtenhagen, F ;
Daumann, J .
BIOLOGICAL PSYCHIATRY, 2002, 51 (09) :766-769
[6]   Multiple toxicity from 3,4-methylenedioxymethamphetamine ("Ecstasy") [J].
Greene, SL ;
Dargan, PI ;
O'Connor, N ;
Jones, AL ;
Kerins, M .
AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2003, 21 (02) :121-124
[7]   Natural antisense RNA inhibits the expression of BCMA, a tumour necrosis factor receptor homologue. [J].
Hatzoglou, Anastassia ;
Deshayes, Frederique ;
Madry, Christine ;
Lapree, Genevieve ;
Castanas, Elias ;
Tsapis, Andreas .
BMC MOLECULAR BIOLOGY, 2002, 3
[8]   Serotonergic neurotoxic metabolites of ecstasy identified in rat brain [J].
Jones, DC ;
Duvauchelle, C ;
Ikegami, A ;
Olsen, CM ;
Lau, SS ;
de la Torre, R ;
Monks, TJ .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 313 (01) :422-431
[9]  
Mas M, 1999, J PHARMACOL EXP THER, V290, P136
[10]   Determination of MDMA and its metabolites in blood and urine by gas chromatography-mass spectrometry and analysis of enantiomers by capillary electrophoresis [J].
Pizarro, N ;
Ortuño, J ;
Farré, M ;
Hernández-López, C ;
Pujadas, M ;
Llebaria, A ;
Joglar, J ;
Roset, PN ;
Mas, M ;
Segura, J ;
Camí, J ;
de la Torre, R .
JOURNAL OF ANALYTICAL TOXICOLOGY, 2002, 26 (03) :157-165