Ru-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes via P-Chiral Monophosphorous Ligands

被引：5
|
作者：
Miao, Rui [1 ]
Xia, Yanping [1 ]
Wei, Yifei [1 ]
Ouyang, Lu [1 ]
Luo, Renshi [1 ,2 ]
机构：
[1] Gannan Med Univ, Sch Pharm, Ganzhou 341000, Peoples R China
[2] Shaoguan Univ, Coll Chem & Environm Engn, Shaoguan 512005, Peoples R China
来源：
MOLECULES | 2022年 / 27卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Ru-catalyzed; asymmetric addition; P-chiral monophosphorous ligands; chiral alcohols; TRANSFER HYDROGENATION; SECONDARY ALCOHOLS; ENANTIOSELECTIVE SYNTHESIS; ORGANOBORONIC ACIDS; EFFICIENT SYNTHESIS; CARBONYL-COMPOUNDS; GRIGNARD-REAGENTS; BETA-ALKYLATION; OLEFIN LIGANDS; ARYLATION;
D O I：
10.3390/molecules27123898
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chiral alcohols are among the most widely applied in fine chemicals, pharmaceuticals and agrochemicals. Herein, the Ru-monophosphine catalyst formed in situ was found to promote an enantioselective addition of aliphatic aldehydes with arylboronic acids, delivering the chiral alcohols in excellent yields and enantioselectivities and exhibiting a broad scope of aliphatic aldehydes and arylboronic acids. The enantioselectivities are highly dependent on the monophosphorous ligands. The utility of this asymmetric synthetic method was showcased by a large-scale transformation.
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页数：18
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