Hemin Treatment Ameliorates Doxorubicin-Induced Cardiotoxicity in Rats

被引：0

作者：

Alkhoufi, Emad A. ^{[1
]}

机构：

[1] King Faisal Univ, Coll Med, Dept Internal Med, Al Hasa, Saudi Arabia

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2020年 / 39卷 / 02期

关键词：

cardiotoxicity; doxorubicin; hemin; rats; NITRIC-OXIDE; INDUCED HEPATOTOXICITY; OXIDATIVE STRESS; OXYGENASE-1; INDUCTION; SUPPRESSION; ANTIOXIDANT;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The protective effect of hemin, a heme oxygenase-1 inducer, against acute doxorubicin cardiotoxicity was investigated. Cardiac toxicity in rats was induced by a single intraperitoneal injection of doxorubicin (20 mg/kg). Hemin treatment (40 mu mol/kg/day, subcutaneously) was started 7 days before doxorubicin administration and continued for 10 consecutive days, which resulted in a reduction of the elevated serum creatine kinase level. Additionally, hemin significantly reduced the levels of malondialdehyde, nitric oxide, tumor necrosis factor-alpha, caspase-3, and Bax/Bcl-2 ratio, and prevented the decrease of total antioxidant status in doxorubicin-challenged rats. It was concluded that hemin, through its antioxidant, anti-inflammatory, and anti-apoptotic activities, protected against doxorubicin cardiotoxicity.

引用

页码：314 / 317

页数：4

共 25 条

[1] Amelioration of doxorubicin-induced cardiotoxicity by deferiprone in rats [J].

Ammar, El-Sayed M. ;

Said, Shehta A. ;

Suddek, Ghada M. ;

El-Damarawy, Sally L. .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2011, 89 (04) :269-276

[2] Acute doxorubicin cardiotoxicity is successfully treated with the phytochemical oleuropein through suppression of oxidative and nitrosative stress [J].

Andreadou, Ioanna ;

Sigala, Fragiska ;

Iliodromitis, Efstathios K. ;

Papaefthimiou, Maria ;

Sigalas, Constantinos ;

Aligiannis, Nektarios ;

Savvari, Paraskevi ;

Gorgoulis, Vassilis ;

Papalabros, Efstathios ;

Kremastinos, Dimitrios. Th. .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2007, 42 (03) :549-558

[3] Acute cardiotoxicity induced by doxorubicin in right ventricle is associated with increase of oxidative stress and apoptosis in rats [J].

Anghel, N. ;

Herman, H. ;

Balta, C. ;

Rosu, M. ;

Stan, M. S. ;

Nita, D. ;

Ivan, A. ;

Galajda, Z. ;

Ardelean, A. ;

Dinischiotu, A. ;

Hermenean, A. .

HISTOLOGY AND HISTOPATHOLOGY, 2018, 33 (04) :365-378

[4] Induction of heme-oxygenase 1 inhibits endothelial cell activation by endotoxin and oxidant stress [J].

Bulger, EM ;

Garcia, I ;

Maier, RV .

SURGERY, 2003, 134 (02) :146-152

[5] An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen [J].

Chan, KM ;

Han, XD ;

Kan, YW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (08) :4611-4616

[6] Hemin, a heme oxygenase-1 inducer, improves aortic endothelial dysfunction in insulin resistant rats [J].

Chen Yong-Song ;

Zhu Xu-Xin ;

Zhao Xiao-Yun ;

Xing Han-Ying ;

Li Yu-Guang .

CHINESE MEDICAL JOURNAL, 2008, 121 (03) :241-247

[7] Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induced hepatotoxicity in the rat: Effects of hemin and biliverdin [J].

Chiu, H ;

Brittingham, JA ;

Laskin, DL .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2002, 181 (02) :106-115

[8]

CLANCY RM, 1995, P SOC EXP BIOL MED, V210, P93

[9]

Florczyk UM, 2008, PHARMACOL REP, V60, P38

[10] Induction of heme oxygenase-1 can act protectively against cardiac ischemia/reperfusion in vivo [J].

Hangaishi, M ;

Ishizaka, N ;

Aizawa, T ;

Kurihara, Y ;

Taguchi, J ;

Nagai, R ;

Kimura, S ;

Ohno, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 279 (02) :582-588

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