Trichomonas vaginalis harboring Mycoplasma hominis increases cytopathogenicity in vitro

被引：27

作者：

Vancini, R. G. ^{[1
,2
]}

Pereira-Neves, A. ^{[1
,2
]}

Borojevic, R. ^{[1
]}

Benchimol, M. ^{[2
]}

机构：

[1] Univ Fed Rio de Janeiro, Programa Posgrad Ciencias Morfol, Rio De Janeiro, Brazil

[2] Univ Santa Ursula, Lab Ultraestrutura Celular, Rio De Janeiro, Brazil

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2008年 / 27卷 / 04期

关键词：

Trichomonas vaginalis; mycoplasmas; vaginal epithelial cells; cytopathogenicity;

D O I：

10.1007/s10096-007-0422-1

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The parasite Trichomonas vaginalis causes one of the most common non-viral sexually transmitted infections in humans. Mycoplasmas are frequently found with trichomonads but the consequences of this association are not yet known. In the present study, the effects of T. vaginalis harboring M. hominis on human vaginal epithelial cells and on MDCK cells are described. The results were analyzed by light, scanning and transmission electron microscopy, as well as using cell viability assays. There was an increase in the cytopathic effects on the epithelial cells infected with T. vaginalis associated with M. hominis compared to T. vaginalis alone. The epithelial cells exhibited an increase in the intercellular spaces, a lesser viability, and increased destruction provoked by the infected T. vaginalis. In addition, the trichomonads presented a higher amoeboid transformation rate and an intense phagocytic activity, characteristics of higher virulence behavior.

引用

页码：259 / 267

页数：9

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