Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligands

被引：110

作者：

Berry, David J. ^{[1
]}

Ma, Yongmin ^{[1
,2
]}

Ballinger, James R. ^{[1
]}

Tavare, Richard ^{[1
]}

Koers, Alexander ^{[1
]}

Sunassee, Kavitha ^{[1
]}

Zhou, Tao ^{[2
]}

Nawaz, Saima ^{[1
]}

Mullen, Gregory E. D. ^{[1
]}

Hider, Robert C. ^{[2
]}

Blower, Philip J. ^{[1
]}

机构：

[1] Kings Coll London, St Thomas Hosp, Rayne Inst, Div Imaging Sci & Biomed Engn, London SE1 7EH, England

[2] Kings Coll London, Inst Pharmaceut Sci, London SE1 9NH, England

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 25期

基金：

英国工程与自然科学研究理事会; 英国惠康基金;

关键词：

SOMATOSTATIN ANALOG; IN-VITRO; PET; COMPLEXATION; AGENT; IRON;

D O I：

10.1039/c1cc12123e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new tripodal tris(hydroxypyridinone) bifunctional chelator for gallium allows easy production of Ga-68-labelled proteins rapidly under mild conditions in high yields at exceptionally high specific activity and low concentration.

引用

页码：7068 / 7070

页数：3

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