Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligands

被引：110
作者：
Berry, David J. [1 ]
Ma, Yongmin [1 ,2 ]
Ballinger, James R. [1 ]
Tavare, Richard [1 ]
Koers, Alexander [1 ]
Sunassee, Kavitha [1 ]
Zhou, Tao [2 ]
Nawaz, Saima [1 ]
Mullen, Gregory E. D. [1 ]
Hider, Robert C. [2 ]
Blower, Philip J. [1 ]
机构：
[1] Kings Coll London, St Thomas Hosp, Rayne Inst, Div Imaging Sci & Biomed Engn, London SE1 7EH, England
[2] Kings Coll London, Inst Pharmaceut Sci, London SE1 9NH, England
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 25期
基金：
英国工程与自然科学研究理事会; 英国惠康基金;
关键词：
SOMATOSTATIN ANALOG; IN-VITRO; PET; COMPLEXATION; AGENT; IRON;
D O I：
10.1039/c1cc12123e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new tripodal tris(hydroxypyridinone) bifunctional chelator for gallium allows easy production of Ga-68-labelled proteins rapidly under mild conditions in high yields at exceptionally high specific activity and low concentration.
引用
收藏
页码：7068 / 7070
页数：3
相关论文
共 19 条
  • [1] Acyclic Chelate with Ideal Properties for 68Ga PET Imaging Agent Elaboration
    Boros, Eszter
    Ferreira, Cara L.
    Cawthray, Jacqueline F.
    Price, Eric W.
    Patrick, Brian O.
    Wester, Dennis W.
    Adam, Michael J.
    Orvig, Chris
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (44) : 15726 - 15733
  • [2] The 68Ge/68Ga generator has high potential, but when can we use 68Ga-labelled tracers in clinical routine?
    Breeman, Wouter A. P.
    Verbruggen, Alfons M.
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2007, 34 (07) : 978 - 981
  • [3] A gallium complex with a new tripodal tris-hydroxypyridinone for potential nuclear diagnostic imaging solution and in vivo studies of 67Ga-labeled species
    Chaves, Silvia
    Mendonca, Ana C.
    Marques, Sergio M.
    Isabel Prata, M.
    Santos, Ana C.
    Martins, Andre F.
    Geraldes, Carlos F. G. C.
    Amelia Santos, M.
    [J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 2011, 105 (01) : 31 - 38
  • [4] New Tris(hydroxypyridinones) as Iron and Aluminium Sequestering Agents: Synthesis, Complexation and In Vivo Studies
    Chaves, Silvia
    Marques, Sergio M.
    Matos, Andre M. F.
    Nunes, Andreia
    Gano, Lurdes
    Tuccinardi, Tiziano
    Martinelli, Adriano
    Amelia Santos, M.
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (34) : 10535 - 10545
  • [5] Tetrafluorophenolate of HBED-CC:: a versatile conjugation agent for 68Ga-labeled small recombinant antibodies
    Eder, Matthias
    Waengler, Bjoern
    Knackmuss, Stefan
    LeGall, Fabrice
    Little, Melvyn
    Haberkorn, Uwe
    Mier, Walter
    Eisenhut, Michael
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2008, 35 (10) : 1878 - 1886
  • [6] NODAGATOC, a new chelator-coupled somatostatin analogue labeled with [67/68Ga] and [111In] for SPECT, PET, and targeted therapeutic applications of somatostatin receptor (hsst2) expressing tumors
    Eisenwiener, KP
    Prata, MIM
    Buschmann, I
    Zhang, HW
    Santos, AC
    Wenger, S
    Reubi, JC
    Mäcke, HR
    [J]. BIOCONJUGATE CHEMISTRY, 2002, 13 (03) : 530 - 541
  • [7] Heppeler A, 1999, CHEM-EUR J, V5, P1974, DOI 10.1002/(SICI)1521-3765(19990702)5:7<1974::AID-CHEM1974>3.3.CO
  • [8] 2-O
  • [9] Labelling of a monoclonal antibody with 68Ga using three DTPA-based bifunctional ligands and their in vitro evaluation for application in radioimmunotherapy
    Koop, B.
    Reske, S. N.
    Neumaier, B.
    [J]. RADIOCHIMICA ACTA, 2007, 95 (01) : 39 - 42
  • [10] Kowalski Jorg, 2003, Mol Imaging Biol, V5, P42, DOI 10.1016/S1536-1632(03)00038-6
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