Metformin-induced lactic acidosis: no one left behind

被引：30

作者：

Vecchio, Sarah ^{[2
]}

Protti, Alessandro ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Anestesiol Terapia Intens & Sci Derm, I-20122 Milan, Italy

[2] IRCCS Fdn Salvatore Maugeri, Ctr Nazl Informaz Tossicol, Ctr Antiveleni, I-27100 Pavia, Italy

来源：

CRITICAL CARE | 2011年 / 15卷 / 01期

关键词：

LACTATE; CELL;

D O I：

10.1186/cc9404

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Metformin is a safe drug when correctly used in properly selected patients. In real life, however, associated lactic acidosis has been repeatedly, although rarely, reported. The term metformin-induced lactic acidosis refers to cases that cannot be explained by any major risk factor other than drug accumulation, usually due to renal failure. Treatment consists of vital function support and drug removal, mainly achieved by renal replacement therapy. Despite dramatic clinical presentation, the prognosis of metformin-induced lactic acidosis is usually surprisingly good.

引用

页数：2

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