Genetic profiles of killer-cell immunoglobulin-like receptors and HLA ligands in Thai blood donors

被引：3
作者：
Kitpoka, Pimpun [1 ]
Tammakorn, Chutima [1 ]
Chaisri, Suwit [2 ,3 ]
Leelayuwat, Chanvit [2 ,4 ]
Mongkolsuk, Tasanee [1 ]
Thammanichanond, Duangtawan [1 ]
机构：
[1] Mahidol Univ, Ramathibodi Hosp, Dept Pathol, Histocompatibil & Immunogenet Lab,Fac Med, Rama 6 Rd, Bangkok 10400, Thailand
[2] Khon Kaen Univ, Fac Associated Med Sci, Ctr Res & Dev, Med Diagnost Labs CMDL, Khon Kaen 40002, Thailand
[3] Thammasat Univ, CICM, Rangsit Campus, Pathum Thani 12120, Thailand
[4] Khon Kaen Univ, Fac Associated Med Sci, Dept Clin Immunol & Transfus Sci, Khon Kaen 40002, Thailand
来源：
HUMAN IMMUNOLOGY | 2016年 / 77卷 / 06期
关键词：
KIR; HLA ligand; NK cell receptor; Haplotype; Thai; KIR HAPLOTYPES; CLASS-I; POPULATION; DIVERSITY; TRANSPLANTATION; DISEASE; POLYMORPHISMS; RECOGNITION; FAMILIES; IMPROVE;
D O I：
10.1016/j.humimm.2016.04.019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Killer-cell immunoglobulin-like receptors (KIRs) play an important role in natural killer (NK) cell regulation. Interaction of KIRs with human leukocyte antigen (HLA) class I molecules can transmit signals to regulate the function of NK cells. In this study, the diversities of KIR genes and their ligands in 500 Thai blood donors were investigated. The coexistence of inhibitory KIRs (iKIR), activating KIRs (aKIR) and their ligands in the same individuals were also analyzed. Overall, 36 KIR genotypes were identified. The most common genotype was genotype AA1 (40.8%). All individuals carried at least one iKIR-HLA pair whereas 18% of the individuals lacked aKIR-HLA pair. The most common compound KIR-HLA profile was the presence of 3 iKIR-HLA pairs with 1 aKIR-HLA pair (21.4%). The most common compound gene profile of KIR-HLA pairs was the combined presence of KIR2DL3-C1, 3DL1-Bw4, 3DL2-A3/A11 and the full length KIR2DS4-its ligands (8%). This study provided a comprehensive analysis of the KIR-HLA profiles in Thai blood donors in regards to KIR genotypes, HLA ligands, KIR-HLA ligand pairs and compound gene profiles of both iKIRs and aKIRs and their ligands. These findings will be useful as baseline information for further studies in the associations of KIR genes and various diseases. (C) 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：470 / 475
页数：6
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