Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system

被引：65

作者：

Boekhoven, Job ^{[1
,2
]}

Zha, R. Helen ^{[1
,3
]}

Tantakitti, Faifan ^{[1
,3
]}

Zhuang, Ellen ^{[2
]}

Zandi, Roya ^{[2
]}

Newcomb, Christina J. ^{[1
]}

Stupp, Samuel I. ^{[1
,2
,3
,4
]}

机构：

[1] Simpson Querrey Inst BioNanotechnol, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Biomed Engn, Dept Chem Engn, Dept Chem, Evanston, IL 60208 USA

[3] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA

[4] Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA

来源：

RSC ADVANCES | 2015年 / 5卷 / 12期

关键词：

SMALL MOLECULES; NANOFIBERS;

D O I：

10.1039/c4ra16593d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of peptide amphiphile nanofibres functionalized for targeting the folate receptor. The spherical geometry of the particle core allows high drug loading per surface area, whereas the nanoscale fibrous shell formed by self-assembly of peptide amphiphiles offers a high surface to volume ratio that is ideal for targeting. The synthesised microparticles have a 60-fold higher cytotoxicity against MDA-MB-231 breast cancer cells compared to non-targeting particles.

引用

页码：8753 / 8756

页数：4

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