Incidence and significance of FLT3-ITD and NPM1 mutations in patients with normal karyotype acute myeloid leukaemia

被引：5

作者：

Haslam, K. ^{[1
]}

Chadwick, N. ^{[2
]}

Kelly, J. ^{[3
]}

Browne, P. ^{[2
]}

Vandenberghe, E. ^{[2
]}

Flynn, C. ^{[2
]}

Conneally, E. ^{[2
]}

Langabeer, S. E. ^{[1
]}

机构：

[1] St James Hosp, Cent Pathol Lab, Dublin 8, Ireland

[2] St James Hosp, Dept Haematol, Dublin 8, Ireland

[3] Our Ladys Childrens Hosp, Natl Ctr Med Genet, Dublin, Ireland

来源：

IRISH JOURNAL OF MEDICAL SCIENCE | 2010年 / 179卷 / 04期

关键词：

AML; Nucleophosmin; FLT3-ITD; Normal karyotype; Prognosis; Genotype; INTERNAL TANDEM DUPLICATION; ACUTE MYELOGENOUS LEUKEMIA; NORMAL CYTOGENETICS; GENE-MUTATIONS; ADULT PATIENTS; AML; 10; NUCLEOPHOSMIN; PROGNOSIS; IMPACT;

D O I：

10.1007/s11845-010-0567-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haematopoietic progenitor cells. Approximately half of all adult AML patients have a normal karyotype (NK-AML) and an intermediate risk prognosis. To determine the incidence and prognostic significance of NPM1 and FLT3-ITD mutations in a population of patients with NK-AML. FLT3-ITD and NPM1 mutation status was retrospectively sought in presentation samples from 44 NK-AML patients. FLT3-ITD and NPM1 mutations were detected in 45.5 and 54.5% of patients, respectively, allowing stratification according to genotype. FLT3-ITD and NPM1 mutation status can be defined in NK-AML. Prospective screening for these mutations is advocated in all NK-AML patients, as the genotype is of clinical importance when considering treatment options including stem cell transplantation.

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收藏

页码：507 / 510

页数：4

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