共 68 条
Low Expression of Stanniocalcin 1 (STC-1) Protein Is Associated With Poor Clinicopathologic Features of Endometrial Cancer
被引:8
作者:
Khatun, Masuma
[1
]
Urpilainen, Elina
[1
]
Ahtikoski, Anne
[2
,3
]
Arffman, Riikka K.
[1
]
Pasanen, Annukka
[4
]
Puistola, Ulla
[1
]
Tapanainen, Juha S.
[1
,5
,6
]
Andersson, Leif C.
[4
]
Butzow, Ralf
[4
]
Loukovaara, Mikko
[5
,6
]
Piltonen, Terhi T.
[1
]
机构:
[1] Univ Oulu, Oulu Univ Hosp, Dept Obstet & Gynaecol, PEDEGO Res Unit,Med Res Ctr, Oulu, Finland
[2] Univ Oulu, Oulu Univ Hosp, Dept Pathol, Oulu, Finland
[3] Turku Univ Hosp, Dept Pathol, Turku, Finland
[4] Univ Helsinki, Dept Pathol, Helsinki, Finland
[5] Helsinki Univ Hosp, Dept Obstet & Gynaecol, Helsinki, Finland
[6] Univ Helsinki, Helsinki, Finland
基金:
芬兰科学院;
关键词:
stanniocalcin-1;
uterine cancer;
type 2 diabetes mellitus;
disease-specific survival;
endometrioid carcinoma;
metformin;
RENAL ISCHEMIA/REPERFUSION INJURY;
ELEVATED EXPRESSION;
GENE-EXPRESSION;
METFORMIN;
CARCINOMA;
BIOMARKER;
INVASION;
CELLS;
D O I:
10.3389/pore.2021.1609936
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Stanniocalcin-1 (STC-1) is a glycoprotein hormone involved in diverse biological processes, including regulation of calcium phosphate homeostasis, cell proliferation, apoptosis, inflammation, oxidative stress responses, and cancer development. The role of STC-1 in endometrial cancer (EC) is yet to be elucidated. In this study, we investigated the protein expression pattern of STC-1 in a tissue microarray (TMA) cohort of hysterectomy specimens from 832 patients with EC. We then evaluated the prognostic value of STC-1 expression regarding the clinicopathologic features and patients survival over a period of 140 months. Our results revealed that in EC tissue samples, STC-1 is mainly localized in the endometrial epithelium, although some expression was also observed in the stroma. Decreased STC-1 expression was associated with factors relating to a worse prognosis, such as grade 3 endometrioid tumors (p = 0.030), deep myometrial invasion (p = 0.003), lymphovascular space invasion (p = 0.050), and large tumor size (p = 0.001). Moreover, STC-1 expression was decreased in tumors obtained from obese women (p = 0.014) and in women with diabetes mellitus type 2 (DMT2; p = 0.001). Interestingly, the data also showed an association between DNA mismatch repair (MMR) deficiency and weak STC-1 expression, specifically in the endometrial epithelium (p = 0.048). No association was observed between STC-1 expression and disease-specific survival. As STC-1 expression was particularly low in cases with obesity and DMT2 in the TMA cohort, we also evaluated the correlation between metformin use and STC-1 expression in an additional EC cohort that only included women with DMT2 (n = 111). The analysis showed no difference in STC-1 expression in either the epithelium or the stroma in women undergoing metformin therapy compared to metformin non-users. Overall, our data may suggest a favorable role for STC-1 in EC behavior; however, further studies are required to elucidate the detailed mechanism and possible applications to cancer treatment.
引用
收藏
页数:9
相关论文