Regulation of food intake by inflammatory cytokines in the brain

被引：48
作者：
Buchanan, Jessica B.
Johnson, Rodney W.
机构：
[1] Univ Illinois, Lab Integrat Immunol & Behav, Dept Anim Sci, Urbana, IL 61801 USA
[2] Univ Illinois, Div Nutr Sci, Urbana, IL USA
来源：
NEUROENDOCRINOLOGY | 2007年 / 86卷 / 03期
关键词：
inflammatory cytokines; feeding; cachexia; hypothalamus;
D O I：
10.1159/000108280
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A number of inflammatory cytokines are synthesized and released after activation of the immune system. In addition to other biological effects, these cytokines can potently inhibit food intake. Cytokine-mediated inhibition of food intake is of particular importance because excessive production of peripheral inflammatory cytokines is often associated with the cachexia-anorexia syndrome seen in some chronic diseases. The weight loss in cachexia is associated with an increase in morbidity and mortality. Understanding how cytokines regulate food intake may be crucial in enhancing quality of life and facilitating recovery in patients exhibiting cachexia. This review describes the main inflammatory cytokines that influence food intake and explores how peripheral cytokines communicate with hypothalamic nuclei to influence feeding. Copyright (C) 2007 S. Karger AG, Basel
引用
收藏
页码：183 / 190
页数：8
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