Force-mediated molecule release from double network hydrogels

被引：17

作者：

Jayathilaka, Pavithra Bhakthi ^{[1
]}

Molley, Thomas Gregory ^{[2
]}

Huang, Yuwan ^{[4
]}

Islam, Md Shariful ^{[2
]}

Buche, Michael Robert ^{[3
]}

Silberstein, Meredith Natania ^{[3
]}

Kruzic, Jamie Joseph ^{[4
]}

Kilian, Kristopher Alan ^{[1
,2
]}

机构：

[1] Univ New South Wales UNSW Sydney, Sch Chem, Australian Ctr Nanomed, Sydney, NSW 2052, Australia

[2] Univ New South Wales UNSW Sydney, Sch Mat Sci, Sydney, NSW 2052, Australia

[3] Cornell Univ, Sibley Sch Mech & Aerosp Engn, Ithaca, NY USA

[4] Univ New South Wales UNSW Sydney, Sch Mech & Mfg Engn, Sydney, NSW 2052, Australia

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 68期

基金：

美国国家科学基金会; 澳大利亚研究理事会;

关键词：

DIELS-ALDER REACTION; MECHANOCHEMICAL ACTIVATION; POLYMER MECHANOCHEMISTRY; COVALENT BONDS; REACTIVITY; TOUGH;

D O I：

10.1039/d1cc02726c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The incorporation of mechanosensitive linkages into polymers has led to materials with dynamic force responsivity. Here we report oxanorbornadiene cross-linked double network hydrogels that release molecules through a force-mediated retro Diels-Alder reaction. The molecular design and tough double network of polyacrylamide and alginate promote significantly higher activation at substantially less force than pure polymer systems. Activation at physiologically relevant forces provides scope for instilling dynamic mechanochemical behavior in soft biological materials.

引用

页码：8484 / 8487

页数：4

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