Histone demethylase JMJD3 at the intersection of cellular senescence and cancer

被引：31

作者：

Perrigue, Patrick M. ^{[1
]}

Najbauer, Joseph ^{[2
]}

Barciszewski, Jan ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Bioorgan Chem, Z Noskowskiego 12-14, PL-61704 Poznan, Poland

[2] Univ Pecs, Sch Med, Dept Immunol & Biotechnol, Pecs, Hungary

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2016年 / 1865卷 / 02期

关键词：

Cancer; Senescence; Inflammation; Aging; Jumonji; JMJD3; SASP; H3K27; DNA-DAMAGE; H3K27ME3; DEMETHYLASE; INFLAMMATORY GENES; INK4A/ARF LOCUS; INK4A-ARF LOCUS; EXPRESSION; CELLS; APOPTOSIS; DIFFERENTIATION; INHIBITION;

D O I：

10.1016/j.bbcan.2016.03.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular senescence is defined by an irreversible growth arrest and is an important biological mechanism for suppression of tumor formation. Although deletion/mutation to DNA sequences is one mechanism by which cancer cells can escape senescence, little is known about the epigenetic factors contributing to this process. Histone modifications and chromatin remodeling related to the function of a histone demethylase, jumonji domain containing protein 3 (JMJD3; also known as KDM6B), play an important role in development, tissue regeneration, stem cells, inflammation, and cellular senescence and aging. The role of JMJD3 in cancer is poorly understood and its function may be at the intersection of many pathways promoted in a dysfunctional manner such as activation of the senescence-associated secretory phenotype (SASP) observed in aging. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：237 / 244

页数：8

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