First Trimester Maternal Vitamin D Status and Risks of Preterm Birth and Small-For-Gestational Age

被引：19

作者：

Monier, Isabelle ^{[1
,2
]}

Baptiste, Amandine ^{[3
]}

Tsatsaris, Vassilis ^{[4
]}

Senat, Marie-Victoire ^{[5
]}

Jani, Jacques ^{[6
]}

Jouannic, Jean-Marie ^{[7
]}

Winer, Norbert ^{[8
]}

Elie, Caroline ^{[3
]}

Souberbielle, Jean-Claude ^{[9
]}

Zeitlin, Jennifer ^{[1
]}

Benachi, Alexandra ^{[2
]}

机构：

[1] Univ Paris, CRESS, INSERM, INRA, F-75004 Paris, France

[2] Univ Paris Saclay, Antoine Beclere Hosp, AP HP, Dept Obstet & Gynaecol, F-92140 Clamart, France

[3] Necker Enfants Malad Hosp, AP HP, URC CIC Paris Descartes Necker Cochin, F-75015 Paris, France

[4] Paris Descartes Univ, Cochin Hosp, AP HP, Dept Obstet, F-75014 Paris, France

[5] Univ Paris Saclay, Bicetre Hosp, AP HP, Dept Obstet & Gynecol, F-94270 Le Kremlin Bicetre, France

[6] Univ Libre Bruxelles, Dept Obstet & Gynecol, Univ Hosp Brugmann, B-1000 Brussels, Belgium

[7] UPMC Sorbonne Univ, Armand Trousseau Hosp, AP HP, Fetal Medecine Dept, F-75012 Paris, France

[8] Nantes Univ, Univ Hosp Nantes, Dept Obstet & Gynecol, CIC Mere Enfant Nantes,NUN,INRA,UMR 1280,Phan, F-44000 Nantes, France

[9] Necker Enfants Malad Hosp, AP HP, Lab Explorat Fonct, F-75015 Paris, France

来源：

NUTRIENTS | 2019年 / 11卷 / 12期

关键词：

vitamin D; 25-hydroxyvitamin D; pregnancy; preterm birth; small-for-gestational age; skin color; D DEFICIENCY; 25-HYDROXYVITAMIN D; D SUPPLEMENTATION; BACTERIAL VAGINOSIS; NEONATAL OUTCOMES; CLINICAL-PRACTICE; PREGNANCY; FETAL; METAANALYSIS; ASSOCIATION;

D O I：

10.3390/nu11123042

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Maternal 25-hydroxyvitamin D (25-OHD) deficiency during pregnancy may increase the risk of preterm and small-for-gestational age (SGA) birth, but studies report conflicting results. We used a multicenter prospective cohort of 2813 pregnant women assessed for 25-OHD levels in the first trimester of pregnancy to investigate the association between maternal 25-OHD concentrations and risks of preterm birth (<37 weeks) and SGA (birthweight <10th percentile). Odds ratios were adjusted (aOR) for potential cofounders overall and among women with light and dark skin separately, based on the Fitzpatrick scale. 25-OHD concentrations were <20 ng/mL for 45.1% of the cohort. A total of 6.7% of women had a preterm birth. The aOR for preterm birth associated with the 1st quartile of 25-OHD concentrations compared to the 4th quartile was 1.53 (95% confidence interval (CI): 0.97-2.43). In stratified analyses, an association was observed for women with darker skin (aOR = 2.89 (95% CI: 1.02-8.18)), and no association with lighter skin. A total of 11.9% of births were SGA and there was no association overall or by skin color. Our results do not provide support for an association between maternal first trimester 25-OHD deficiency and risk of preterm or SGA birth overall; the association with preterm birth risk among women with darker skin requires further investigation.

引用

页数：13

共 53 条

[1] Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies [J].