Neferine alleviates P2X3 receptor in rat dorsal root ganglia mediated neuropathic pain

被引:11
|
作者
Dan, Yu [1 ,2 ]
Guo, Hongmin [1 ]
Zheng, Chaoran [1 ]
Wu, Baoguo [1 ]
Guo, Jingjing [1 ]
Li, Guilin [1 ]
机构
[1] Nanchang Univ, Dept Physiol, Med Sch, 461 Bayi Rd, Nanchang 330006, Jiangxi, Peoples R China
[2] Union Dongxihu Hosp, Dept Lab Med Dept, Wuhan, Hubei, Peoples R China
基金
中国国家自然科学基金;
关键词
Dorsal root ganglia; Neferine; A-317491; Neuropathic pain; P2X(2/3) RECEPTOR; P2X(3) RECEPTOR; A-317491; NEURONS; TRANSMISSION; MECHANISMS; CELLS; TETRAMETHYLPYRAZINE; PATHOPHYSIOLOGY; ANTAGONIST;
D O I
10.1016/j.neures.2020.08.004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Chronic neuropathic pain is caused by tissue damage or nervous system inflammation and is characterized by sensitivity to painful stimuli. P2X3 receptors play an important role in facilitating pain transmission. Neferine is a bisbenzylisoquinline alkaloid isolated from seed embryos of lotus, which has anti-inflammatory and anti-oxidation pharmacological functions. The present research investigated whether neferine relieves neuropathic pain related to the P2X3 receptor in rat dorsal root ganglia (DRGs). Chronic contraction injury (CCI) in rats was used as a model for neuropathic pain. The results indicated that the expression of P2X3 receptor was significantly increased in the DRGs of CCI rats and that mechanical allodynia and thermal hyperalgesia were also enhanced in CCI rats. Neferine markedly lowered the upregulated P2X3 receptor and interleukin-1beta, inhibited the phosphorylation and activation of ERK1/2 in the DRGs of CCI rats, and relieved neuropathic pain. Therefore, neferine alleviates neuropathic pain by downregulating the expression of P2X3 receptor. (c) 2020 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
引用
收藏
页码:265 / 272
页数:8
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