Revisited Synthesis of Aryl-H-phosphinates

被引：12

作者：

Volle, Jean-Noel ^{[1
]}

Filippini, Damien ^{[1
]}

Midrier, Camille ^{[1
]}

Sobecki, Michal ^{[2
]}

Drag, Marcin ^{[2
]}

Virieux, David ^{[1
]}

Pirat, Jean-Luc ^{[1
]}

机构：

[1] ENSCM, Inst Charles Gerhardt, UMR5253, AM2N, F-34296 Montpellier 5, France

[2] Wroclaw Univ Technol, Fac Chem, Dept Med Chem & Microbiol, PL-50370 Wroclaw, Poland

来源：

SYNTHESIS-STUTTGART | 2011年 / 15期

关键词：

phosphonites; phosphinates; aryl-H-phosphinates; triethyl phosphite; hydrolysis; Grignard reagent; ACID; ESTERS; HALIDES; BOND;

D O I：

10.1055/s-0030-1260109

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A systematic study of the reaction conditions for the preparation of pure aryl-H-phosphinate esters, originally developed by Sander and optimized by Petnehazy, is reported. The influence of the reaction concentration has been investigated for the formation of phosphonite intermediates via direct addition of triethyl phosphite to the appropriate Grignard reagent. Subsequent hydrolysis of the phosphonites under acidic conditions gives various aryl-H-phosphinates in high yields and purities.

引用

页码：2490 / 2494

页数：5

共 20 条

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