Comparison of the Genomic Profile of Cancer Stem Cells and Their Non-Stem Counterpart: The Case of Ovarian Cancer

被引：7

作者：

Mazzoldi, Elena Laura ^{[1
,5
]}

Pasto, Anna ^{[1
,6
]}

Pilotto, Giorgia ^{[1
]}

Minuzzo, Sonia ^{[2
]}

Piga, Ilaria ^{[1
,2
]}

Palumbo, Pietro ^{[3
]}

Carella, Massimo ^{[3
]}

Frezzini, Simona ^{[4
]}

Nicoletto, Maria Ornella ^{[4
]}

Amadori, Alberto ^{[1
,2
]}

Indraccolo, Stefano ^{[1
]}

机构：

[1] IRCCS, Veneto Inst Oncol IOV, Immunol & Mol Oncol Unit, I-35128 Padua, Italy

[2] Univ Padua, Dept Surg Oncol & Gastroenterol, I-35128 Padua, Italy

[3] Fdn IRCCS Casa Sollievo Sofferenza, Med Genet Unit, I-71013 San Giovanni Rotondo, Italy

[4] IRCCS, Veneto Inst Oncol IOV, Med Oncol 2, I-35128 Padua, Italy

[5] Univ Brescia, Dept Mol & Translat Med, I-25123 Brescia, Italy

[6] Humanitas Clin & Res Ctr, Dept Inflammat & Immunol, I-20089 Milan, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 02期

关键词：

ovarian cancer; cancer stem cell; genetic heterogeneity; SNP array;

D O I：

10.3390/jcm9020368

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The classical cancer stem cell (CSC) model places CSCs at the apex of a hierarchical scale, suggesting different genetic alterations in non-CSCs compared to CSCs, since an ill-defined number of cell generations and time intervals separate CSCs from the more differentiated cancer cells that form the bulk of the tumor. Another model, however, poses that CSCs should be considered a functional state of tumor cells, hence sharing the same genetic alterations. Here, we review the existing literature on the genetic landscape of CSCs in various tumor types and as a case study investigate the genomic complexity of DNA obtained from matched CSCs and non-CSCs from five ovarian cancer patients, using a genome-wide single-nucleotide polymorphism (SNP) microarray.

引用

页数：10

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