The impact of a new universal infant and school-based adolescent hepatitis B vaccination program in Australia

被引：40

作者：

Gidding, Heather F. ^{[1
]}

Warlow, Margaret ^{[2
,3
]}

MacIntyre, C. Raina ^{[2
,3
]}

Backhouse, Josephine ^{[1
]}

Gilbert, Gwendolyn L. ^{[1
]}

Quinn, Helen E. ^{[2
,3
]}

McIntyre, Peter B. ^{[2
]}

机构：

[1] Westmead Hosp, Ctr Infect Dis & Microbiol, Publ Hlth & Inst Clin Pathol, Westmead, NSW 2145, Australia

[2] Childrens Hosp, Natl Ctr Immunisat Res & Surveillance Vaccine Pre, Westmead, NSW 2145, Australia

[3] Univ Sydney, Westmead, NSW 2145, Australia

来源：

VACCINE | 2007年 / 25卷 / 51期

关键词：

hepatitis B; seroepidemiologic studies; Australia;

D O I：

10.1016/j.vaccine.2007.07.046

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We compared the results of two national serosurveys in Australia to evaluate the impact of universal infant vaccination and school-based programs for adolescents. Immunity improved significantly overall, especially in 1-year-olds (40.0% versus 86%; p < 0.0001); in adolescents it was significantly higher in regions with established school-based programs (56.6% versus 38.8%; p = 0.0008). 6.1% of 1-59-year-olds were positive for HBcAb and 0.7% for HBsAg. We have demonstrated successful implementation of universal infant hepatitis B vaccination in Australia and that school-based programs for adolescents are effective. This experience should be applicable to low prevalence countries in northern Europe which have not implemented universal hepatitis B immunisation. (c) 2007 Published by Elsevier Ltd.

引用

页码：8637 / 8641

页数：5

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