Liquid crystalline microspheres for 5-fluorouracil specific release

被引：4
作者：
Cassano, Roberta [1 ]
Nicoletta, Fiore Pasquale [1 ]
Mellace, Silvia [1 ]
Grande, Fedora [1 ]
Picci, Nevio [1 ]
Trombino, Sonia [1 ]
机构：
[1] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Cosenza, Italy
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2017年 / 41卷
关键词：
Fenoprofen; Poloxamer; 5-Fluoruracil; Microspheres; Liquid crystals; Thermosensitive hydrogels; DRUG-DELIVERY SYSTEMS; CANCER-THERAPY; DOXORUBICIN; MICELLES; MICROPARTICLES; TUBERCULOSIS; RIFAMPICIN; CONJUGATE; HYDROGELS; POLYMERS;
D O I：
10.1016/j.jddst.2017.09.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of this study was the synthesis and characterization of swellable microspheres based on fenoprofen and poloxamer. Morphology, average diameter and thermal behaviour of obtained micro particles were studied by scanning electron microscopy, dynamic light scattering, and differential scanning calorimetry. The swelling degree was evaluated at different time intervals and at two pH values. The results revealed that the microspheres swelled better at a pH 6.2, typical of tumour pathologies, than at 7.4, physiological one. Then, microspheres were impregnated with 5-fluorouracil with the aim to increase its bioavailability and reduce its toxicity. The percentage of cumulative amount of 5-fluorouracil released from microparticles was calculated at pH 6.2. Surprisingly, calorimetry and optical microscopy showed the preservation of fenoprofen liquid crystallinity in the obtained microparticles with a transition temperature close to those of typical tumour-sites. The liquid crystallinity of microparticles could be exploited to modulate the release of 5-fluorouracil to tumour site. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：482 / 487
页数：6
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