Research progress on DNA methylation in hepatocellular carcinoma

被引：0

作者：

Zheng, Yongchang ^{[1
]}

Wang, Xin ^{[1
]}

Xie, Feihu ^{[1
]}

Gu, Zhaoqi ^{[1
]}

He, Li ^{[1
]}

Du, Shunda ^{[1
]}

Zhao, Haitao ^{[1
]}

Xu, Yiyao ^{[1
]}

Lu, Xin ^{[1
]}

Mao, Yilei ^{[1
]}

Sang, Xinting ^{[1
]}

Xu, Haifeng ^{[1
]}

Chi, Tianyi ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Liver Surg, Beijing 100730, Peoples R China

来源：

TRANSLATIONAL CANCER RESEARCH | 2017年 / 6卷 / 05期

关键词：

Hepatocellular carcinoma (HCC); methylation; gene chip analysis; whole genome sequencing; early diagnosis; ABERRANT PROMOTER METHYLATION; TUMOR-SUPPRESSOR GENES; EMBRYONIC STEM-CELLS; GENOME-WIDE; LINE-1; HYPOMETHYLATION; EPIGENETIC ALTERATIONS; MULTIPLE GENES; HIGH-THROUGHPUT; HEPATITIS-B; CPG ISLANDS;

D O I：

10.21037/tcr.2017.10.33

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is a common malignant tumor with high incidence and morbidity worldwide. The pathogenesis and progression of HCC are closely related to abnormal epigenetic regulation of hepatocytes. DNA methylation is an important regulatory mechanism in epigenetics which has been deeply and widely investigated. Along with the development of high-throughput sequencing techniques, including high-throughput gene chip analysis and next generation sequencing, great progress was achieved toward the understanding of the epigenetic regulation of HCC. In this article we will systematically summarize the current and emerging research on DNA methylation in HCC.

引用

页码：981 / 998

页数：18

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