Calcific Aortic Valve Stenosis and Atherosclerotic Calcification

被引：45

作者：

Barros de Oliveira Sa, Michel Pompeu ^{[1
,2
,3
,4
]}

Cavalcanti, Luiz Rafael P. ^{[1
,2
]}

Perazzo, Alvaro M. ^{[1
,2
]}

Gomes, Rafael A. F. ^{[1
,2
,3
,4
]}

Clavel, Marie-Annick ^{[5
]}

Pibarot, Philippe ^{[5
]}

Biondi-Zoccai, Giuseppe ^{[6
,7
]}

Zhigalov, Konstantin ^{[8
]}

Weymann, Alexander ^{[8
]}

Ruhparwar, Arjang ^{[8
]}

Lima, Ricardo Carvalho ^{[1
,2
,3
,4
]}

机构：

[1] PROCAPE, Div Cardiovasc Surg Pronto Socorro Cardiol Pernam, Av Eng Domingos Ferreira 4172,Edf Paqueta,Apt 405, BR-51021040 Recife, PE, Brazil

[2] Univ Pernambuco, UPE, Recife, PE, Brazil

[3] FCM ICB, Fac Med Sci, Nucleus Postgrad & Res Hlth Sci, Recife, PE, Brazil

[4] FCM ICB, Biol Sci Inst, Recife, PE, Brazil

[5] Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Quebec Heart & Lung Inst, 2725 Chemin St Foy,A-2075, Quebec City, PQ G1V 4G5, Canada

[6] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, Latina, Italy

[7] Mediterranea Cardioctr, Naples, Italy

[8] Univ Duisburg Essen, Univ Hosp Essen, West German Heart & Vasc Ctr Essen, Dept Thorac & Cardiovasc Surg, Essen, Germany

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2020年 / 22卷 / 02期

关键词：

Aortic valve stenosis; Atherosclerosis; Calcific aortic stenosis; Vascular calcification; LIPOPROTEIN(A); DISEASE; MODELS; MINERALIZATION; INFLAMMATION; PROGRESSION; MECHANISMS; ARTERIAL;

D O I：

10.1007/s11883-020-0821-7

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Purpose of Review This review summarizes the pathophysiology of calcific aortic valve stenosis (CAVS) and surveys relevant clinical data and basic research that explain how CAVS arises. Recent Findings Lipoprotein(a) [Lp(a)], lipoprotein-associated phospholipase A2 (Lp-PLA2), oxidized phospholipids (OxPL), autotaxin, and genetic driving forces such as mutations in LPA gene and NOTCH gene seem to play a major role in the development of CAVS. These factors might well become targets of medical therapy in the coming years. CVAS seems to be a multifactorial disease that has much in common with coronary artery disease, mainly regarding lipidic accumulation and calcium deposition. No clinical trials conducted to date have managed to answer the key question of whether Lp(a) lowering and anti-calcific therapies confer a benefit in terms of reducing incidence or progression of CAVS, although additional outcome trials are ongoing.

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页数：6

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