Novel IκκB kinase inhibitors for treatment of nuclear factor-κκB-related diseases

被引：60

作者：

Suzuki, Jun-ichi ^{[1
]}

Ogawa, Masahito ^{[1
]}

Muto, Susumu ^{[2
]}

Itai, Akiko ^{[2
]}

Isobe, Mitsuaki ^{[3
]}

Hirata, Yasunobu ^{[1
]}

Nagai, Ryozo ^{[4
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Adv Clin Sci & Therapeut, Bunkyo Ku, Tokyo 1138655, Japan

[2] Inst Med Mol Design Inc, Tokyo, Japan

[3] Tokyo Med & Dent Univ, Dept Cardiovasc Med, Tokyo, Japan

[4] Univ Tokyo, Dept Cardiovasc Med, Tokyo 1138655, Japan

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2011年 / 20卷 / 03期

关键词：

chemical compounds; inflammation; I kappa B kinase; NF-kappa B; HIGHLY SELECTIVE INHIBITOR; COLLAGEN-INDUCED ARTHRITIS; DECOY OLIGODEOXYNUCLEOTIDES; GENE-EXPRESSION; MYOCARDIAL-ISCHEMIA; IMATINIB-RESISTANT; THERAPEUTIC TARGET; VIVO TRANSFECTION; ATOPIC-DERMATITIS; LEUKEMIA-CELLS;

D O I：

10.1517/13543784.2011.559162

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Areas covered: NF-kappa kappa B affects the progression of inflammation-related diseases, such as myocardial ischemia, bronchial asthma, arthritis, cancer and other diseases. We review the characteristics and effects of these inhibitors on inflammatory and other diseases. Expert opinion: Various synthesized IKK inhibitors have been developed and they will be used clinically in the near future.

引用

页码：395 / 405

页数：11

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