Novel IκκB kinase inhibitors for treatment of nuclear factor-κκB-related diseases

被引：59
作者：
Suzuki, Jun-ichi [1 ]
Ogawa, Masahito [1 ]
Muto, Susumu [2 ]
Itai, Akiko [2 ]
Isobe, Mitsuaki [3 ]
Hirata, Yasunobu [1 ]
Nagai, Ryozo [4 ]
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Adv Clin Sci & Therapeut, Bunkyo Ku, Tokyo 1138655, Japan
[2] Inst Med Mol Design Inc, Tokyo, Japan
[3] Tokyo Med & Dent Univ, Dept Cardiovasc Med, Tokyo, Japan
[4] Univ Tokyo, Dept Cardiovasc Med, Tokyo 1138655, Japan
来源：
EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2011年 / 20卷 / 03期
关键词：
chemical compounds; inflammation; I kappa B kinase; NF-kappa B; HIGHLY SELECTIVE INHIBITOR; COLLAGEN-INDUCED ARTHRITIS; DECOY OLIGODEOXYNUCLEOTIDES; GENE-EXPRESSION; MYOCARDIAL-ISCHEMIA; IMATINIB-RESISTANT; THERAPEUTIC TARGET; VIVO TRANSFECTION; ATOPIC-DERMATITIS; LEUKEMIA-CELLS;
D O I：
10.1517/13543784.2011.559162
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Areas covered: NF-kappa kappa B affects the progression of inflammation-related diseases, such as myocardial ischemia, bronchial asthma, arthritis, cancer and other diseases. We review the characteristics and effects of these inhibitors on inflammatory and other diseases. Expert opinion: Various synthesized IKK inhibitors have been developed and they will be used clinically in the near future.
引用
收藏
页码：395 / 405
页数：11
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