Synthesis of γ-Lactones by TBAI-Promoted Intermolecular Carboesterification of Carboxylic Acids with Alkenes and Alcohols

被引：6

作者：

Chen, Rongxiang ^{[1
]}

Wang, Kai-Kai ^{[1
]}

Wang, Zhan-Yong ^{[1
]}

Miao, Changqing ^{[1
]}

Wang, Doudou ^{[1
]}

Zhang, An-an ^{[2
]}

Liu, Lantao ^{[2
]}

机构：

[1] Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453000, Henan, Peoples R China

[2] Shangqiu Normal Univ, Coll Chem & Chem Engn, Shangqiu 476000, Henan, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 24期

基金：

中国国家自然科学基金;

关键词：

C-H; IODINE; FUNCTIONALIZATION; LACTONIZATION; ALKYLATION; EFFICIENT; CARBON;

D O I：

10.1021/acs.joc.9b02568

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel tetrabutylammonium iodide (TBAI)-promoted three-component reaction of carboxylic acid with alkene and alcohol has been developed, which represents facile and straightforward access to polysubstituted gamma-lactone skeletons in moderate-to-good yields. This methodology is distinguished by the use of a commercial catalyst and readily available starting materials, wide substrate scope, and operational simplicity. Mechanistic studies suggested that this transformation went through a radical process.

引用

页码：16068 / 16075

页数：8

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