Old drug fluvoxamine, new hope for COVID-19

被引:19
作者
Hashimoto, Yaeko [1 ,2 ]
Suzuki, Takuji [1 ]
Hashimoto, Kenji [2 ]
机构
[1] Chiba Univ, Grad Sch Med, Dept Respirol, Chiba 2608670, Japan
[2] Chiba Univ, Ctr Forens Mental Hlth, Div Clin Neurosci, 1-8-1 Inohana, Chiba 2608670, Japan
关键词
D O I
10.1007/s00406-021-01326-z
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:161 / 163
页数:3
相关论文
共 10 条
[1]   Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms [J].
Gordon, David E. ;
Hiatt, Joseph ;
Bouhaddou, Mehdi ;
Rezelj, Veronica V. ;
Ulferts, Svenja ;
Braberg, Hannes ;
Jureka, Alexander S. ;
Obernier, Kirsten ;
Guo, Jeffrey Z. ;
Batra, Jyoti ;
Kaake, Robyn M. ;
Weckstein, Andrew R. ;
Owens, Tristan W. ;
Gupta, Meghna ;
Pourmal, Sergei ;
Titus, Erron W. ;
Cakir, Merve ;
Soucheray, Margaret ;
McGregor, Michael ;
Cakir, Zeynep ;
Jang, Gwendolyn ;
O'Meara, Matthew J. ;
Tummino, Tia A. ;
Zhang, Ziyang ;
Foussard, Helene ;
Rojc, Ajda ;
Zhou, Yuan ;
Kuchenov, Dmitry ;
Huttenhain, Ruth ;
Xu, Jiewei ;
Eckhardt, Manon ;
Swaney, Danielle L. ;
Fabius, Jacqueline M. ;
Ummadi, Manisha ;
Tutuncuoglu, Beril ;
Rathore, Ujjwal ;
Modak, Maya ;
Haas, Paige ;
Haas, Kelsey M. ;
Naing, Zun Zar Chi ;
Pulido, Ernst H. ;
Shi, Ying ;
Barrio-Hernandez, Inigo ;
Memon, Danish ;
Petsalaki, Eirini ;
Dunham, Alistair ;
Marrero, Miguel Correa ;
Burke, David ;
Koh, Cassandra ;
Vallet, Thomas .
SCIENCE, 2020, 370 (6521) :1181-+
[2]   Repurposing of CNS drugs to treat COVID-19 infection: targeting the sigma-1 receptor [J].
Hashimoto, Kenji .
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2021, 271 (02) :249-258
[3]   Activation of sigma-1 receptor chaperone in the treatment of neuropsychiatric diseases and its clinical implication [J].
Hashimoto, Kenji .
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2015, 127 (01) :6-9
[4]   Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter Study [J].
Hoertel, Nicolas ;
Sanchez-Rico, Marina ;
Gulbins, Erich ;
Kornhuber, Johannes ;
Carpinteiro, Alexander ;
Lenze, Eric J. ;
Reiersen, Angela M. ;
Abellan, Miriam ;
de la Muela, Pedro ;
Vernet, Raphael ;
Blanco, Carlos ;
Cougoule, Celine ;
Beeker, Nathanael ;
Neuraz, Antoine ;
Gorwood, Philip ;
Alvarado, Jesus M. ;
Meneton, Pierre ;
Limosin, Frederic .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2021, 110 (06) :1498-1511
[5]   Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19 A Randomized Clinical Trial [J].
Lenze, Eric J. ;
Mattar, Caline ;
Zorumski, Charles F. ;
Stevens, Angela ;
Schweiger, Julie ;
Nicol, Ginger E. ;
Miller, J. Philip ;
Yang, Lei ;
Yingling, Michael ;
Avidan, Michael S. ;
Reiersen, Angela M. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 324 (22) :2292-2300
[6]   Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain [J].
Narita, N ;
Hashimoto, K ;
Tomitaka, S ;
Minabe, Y .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 307 (01) :117-119
[7]   Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis [J].
Rosen, Dorian A. ;
Seki, Scott M. ;
Fernandez-Castaneda, Anthony ;
Beiter, Rebecca M. ;
Eccles, Jacob D. ;
Woodfolk, Judith A. ;
Gaultier, Alban .
SCIENCE TRANSLATIONAL MEDICINE, 2019, 11 (478)
[8]  
Sax PE., 2021, NEJM J Watch
[9]   Prospective Cohort of Fluvoxamine for Early Treatment of Coronavirus Disease 19 [J].
Seftel, David ;
Boulware, David R. .
OPEN FORUM INFECTIOUS DISEASES, 2021, 8 (02)
[10]   Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19 [J].
Sukhatme, Vikas P. ;
Reiersen, Angela M. ;
Vayttaden, Sharat J. ;
Sukhatme, Vidula V. .
FRONTIERS IN PHARMACOLOGY, 2021, 12