Imprinting molecular recognition sites on multiwalled carbon nanotubes surface for electrochemical detection of insulin in real samples

被引：95

作者：

Prasad, Bhim Bali ^{[1
]}

Madhuri, Rashmi ^{[1
]}

Tiwari, Mahavir Prasad ^{[1
]}

Sharma, Piyush Sindhu ^{[1
]}

机构：

[1] Banaras Hindu Univ, Fac Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India

来源：

ELECTROCHIMICA ACTA | 2010年 / 55卷 / 28期

关键词：

Insulin-imprinted polymer; MWCNTs-MIP; Carbon-MIP modified PGE; Differential pulse anodic stripping; voltammetry; PICOMOLAR DETECTION; ELECTRODE; POLYMERS; SENSOR;

D O I：

10.1016/j.electacta.2010.09.008

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

An insulin-imprinted polymer was synthesized over the surface of vinyl group functionalized multiwalled carbon nanotubes using phosphotidylcholine-containing functional monomer and cross-linker Phosphotidylcholine is a major component of all biological membrane its incorporation in polymer backbone assures water-compatibility bio-compatibility and specificity to molecularly imprinted nanomaterials without any cross-reactivity or interferences from biological sample matrices An electrochemical sensor fabricated by modifying multiwalled carbon nanotubes-molecularly imprinted polymer onto the pencil graphite electrode was used for trace level detection of insulin in aqueous blood serum and pharmaceutical samples (detection limit 0 0186 nmol L(-1) S/N = 3) by differential pulse anodic stripping voltammetry Additional cyclic voltammetry (stripping mode) and chronocoulometry experiments were performed to explore electrodics and kinetics of electro-oxidation of insulin (C) 2010 Elsevier Ltd All rights reserved

引用

页码：9146 / 9156

页数：11

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