How cells get the right chromosomes

被引：499
作者：
Nicklas, RB
机构：
[1] Depts. of Zoology and Cell Biology, LSRC Building, Duke University, Durham
来源：
SCIENCE | 1997年 / 275卷 / 5300期
关键词：
D O I：
10.1126/science.275.5300.632
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
When cells divide, the chromosomes must be delivered flawlessly to the daughter cells. Missing or extra chromosomes can result in birth defects and cancer. Chance events are the starting point for chromosome delivery, which makes the process prone to error, Errors are avoided by diverse uses of mechanical tension from mitotic forces. Tension stabilizes the proper chromosome configuration, controls a cell cycle checkpoint, and changes chromosome chemistry.
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页码：632 / 637
页数：6
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