Cutaneous hyperpigmentation following bleomycin sclerotherapy for vascular malformations

被引：8
作者：
Davis, Kyle P. [1 ]
Gaffey, Megan M. [1 ,2 ,3 ]
Kompelli, Anvesh R. [1 ]
Richter, Gresham T. [1 ,2 ]
机构：
[1] Univ Arkansas Med Sci, Dept Otolaryngol Head & Neck Surg, Little Rock, AR 72205 USA
[2] Arkansas Childrens Hosp, Div Pediat Otolaryngol, 800 Marshall St, Little Rock, AR 72202 USA
[3] NYU, Langone Hlth, Div Pediat Otolaryngol, Dept Otolaryngol Head & Neck Surg, New York, NY USA
来源：
PEDIATRIC DERMATOLOGY | 2022年 / 39卷 / 01期
关键词：
bleomycin; hyperpigmentation; sclerotherapy; vascular malformations; ANESTHESIA;
D O I：
10.1111/pde.14869
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Systemic bleomycin therapy is associated with pulmonary fibrosis and cutaneous side effects. While it is believed that there is little to no systemic distribution of bleomycin when utilized to treat vascular malformations (VMs), we present a case series in which cutaneous, adhesive-related hyperpigmentation suggests that there is systemic egress of bleomycin following direct puncture sclerotherapy (DPS). This risk of hyperpigmentation after intralesional bleomycin should be discussed with patients, and steps to minimize the chances of it occurring should be implemented.
引用
收藏
页码：103 / 106
页数：4
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