Cutaneous hyperpigmentation following bleomycin sclerotherapy for vascular malformations

被引：6
|
作者：
Davis, Kyle P. [1 ]
Gaffey, Megan M. [1 ,2 ,3 ]
Kompelli, Anvesh R. [1 ]
Richter, Gresham T. [1 ,2 ]
机构：
[1] Univ Arkansas Med Sci, Dept Otolaryngol Head & Neck Surg, Little Rock, AR 72205 USA
[2] Arkansas Childrens Hosp, Div Pediat Otolaryngol, 800 Marshall St, Little Rock, AR 72202 USA
[3] NYU, Langone Hlth, Div Pediat Otolaryngol, Dept Otolaryngol Head & Neck Surg, New York, NY USA
来源：
PEDIATRIC DERMATOLOGY | 2022年 / 39卷 / 01期
关键词：
bleomycin; hyperpigmentation; sclerotherapy; vascular malformations; ANESTHESIA;
D O I：
10.1111/pde.14869
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Systemic bleomycin therapy is associated with pulmonary fibrosis and cutaneous side effects. While it is believed that there is little to no systemic distribution of bleomycin when utilized to treat vascular malformations (VMs), we present a case series in which cutaneous, adhesive-related hyperpigmentation suggests that there is systemic egress of bleomycin following direct puncture sclerotherapy (DPS). This risk of hyperpigmentation after intralesional bleomycin should be discussed with patients, and steps to minimize the chances of it occurring should be implemented.
引用
收藏
页码：103 / 106
页数：4
相关论文
共 50 条
  • [1] The Therapeutic Effect of Bleomycin Sclerotherapy in Vascular Malformations
    Alipour, Amirreza
    Shahri, Jamal Jalili
    Mahaki, Hanieh
    INDIAN JOURNAL OF SURGERY, 2024, : 243 - 252
  • [2] Pharmacokinetics of bleomycin sclerotherapy in patients with vascular malformations
    Mack, Joana M.
    Peterson, Eric C.
    Crary, Shelley E.
    Moran, Jeffery H.
    Neville, Kathleen
    Pierce, C. D'ann
    Richter, Gresham T.
    PEDIATRIC BLOOD & CANCER, 2022, 69 (08)
  • [3] Bleomycin sclerotherapy in congenital lymphatic and vascular malformations of head and neck
    Mathur, NN
    Rana, I
    Bothra, R
    Kathuria, G
    Pradhan, T
    INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 2005, 69 (01) : 75 - 80
  • [4] Treatment of deep-seated palatal vascular malformations by bleomycin sclerotherapy
    Agarwal, Rajiv
    Agarwal, Mallika
    Agarwal, Devisha
    Chandra, Ramesh
    Prasad, Raghunandan
    JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 2021, 74 (09) : 2272 - 2278
  • [5] Sclerotherapy for congenital vascular malformations with mixing foam of polidocanol and liquid of bleomycin
    Yang, Wei-Hong
    Xiang, Xian-Jun
    Li, Hai-Lei
    PHLEBOLOGY, 2023, 38 (07) : 451 - 457
  • [6] Patient-Reported Outcomes of Bleomycin Sclerotherapy for Low-Flow Vascular Malformations and Predictors of Improvement
    Horbach, S. E. R.
    van de Ven, J. S.
    Nieuwkerk, P. T.
    Spuls, Ph. I.
    van der Horst, C. M. A. M.
    Reekers, J. A.
    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 2018, 41 (10) : 1494 - 1504
  • [7] Patient-Reported Outcomes of Bleomycin Sclerotherapy for Low-Flow Vascular Malformations and Predictors of Improvement
    S. E. R. Horbach
    J. S. van de Ven
    P. T. Nieuwkerk
    Ph. I. Spuls
    C. M. A. M. van der Horst
    J. A. Reekers
    CardioVascular and Interventional Radiology, 2018, 41 : 1494 - 1504
  • [8] Short-term side effects and patient-reported outcomes of bleomycin sclerotherapy in vascular malformations
    Mack, Joana M.
    Richter, Gresham T.
    Becton, David
    Salem, Omar
    Hill, Sarah E. M.
    Crary, Shelley E.
    PEDIATRIC BLOOD & CANCER, 2018, 65 (06)
  • [9] Single center experience with intralesional bleomycin sclerotherapy for lymphatic malformations
    Yilmaz, Hakan
    Yilmaz, Ozlem
    Camlidag, Ilkay
    Belet, Umit
    Akan, Huseyin
    JAPANESE JOURNAL OF RADIOLOGY, 2017, 35 (10) : 590 - 596
  • [10] Interstitial bleomycin sclerotherapy in children with vascular malformations: Our initial experience in Hong Kong
    Chan, Yick Ting
    Leung, Yvonne Chi Lun
    Fung, Hon Shing
    Poon, Wai Lun
    Yuen, Hunter Kwok Lai
    Leung, Michael Wai Yip
    SURGICAL PRACTICE, 2023, 27 (01) : 40 - 47
12345