Establishment of a new cell line of endometrioid carcinoma of the ovary and its chemosensitivity

被引：10

作者：

Umezu, Tomokazu ^{[1
]}

Kajiyama, Hiroaki ^{[1
]}

Terauchi, Mikio ^{[1
]}

Shibata, Kiyosumi ^{[1
]}

Ino, Kazuhiko ^{[1
]}

Nawa, Akihiro ^{[1
]}

Kikkawa, Fumitaka ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Obstet & Gynaecol, Showa Ku, Nagoya, Aichi 4668550, Japan

来源：

HUMAN CELL | 2007年 / 20卷 / 03期

关键词：

chemosensitivity; endometrioid carcinoma; establishment; nude mouse; ovarian carcinoma;

D O I：

10.1111/j.1749-0774.2007.00030.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A new cell line (NOE) of human ovarian endometrioid carcinoma was established and characterized. The cell line showed a short spindle-shaped morphology and continued to grow for more than 4 months without contact inhibition. The doubling time was approximately 15.5 h at the 10th passage. The chromosome number was aneuploid. The IC50 values of paclitaxel, cisplatin and carboplatin were 26.4 mu g/mL, 2.4 mu g/mL and 32.5 mu g/mL, respectively. The NOE cells expressed estrogen receptor alpha. In nude mice, we confirmed tumor formation of NOE cells. These results indicated that NOE cells showed similar chemosensitivity and properties to those of the original tumor and might be useful in basic studies on the diagnosis, treatment and etiology of ovarian tumors.

引用

页码：71 / 76

页数：6

共 50 条

[1] Establishment of a new cell line of endometrioid carcinoma of the ovary and its chemosensitivity
Tomokazu Umezu
Hiroaki Kajiyama
Mikio Terauchi
Kiyosumi Shibata
Kazuhiko Ino
Akihiro Nawa
Fumitaka Kikkawa
Human Cell, 2007, 20 : 71 - 76
[2] Establishment and characterization of a new cell line (SKS) from neuroendocrine small cell carcinoma of the uterine cervix and its chemosensitivity
Saga, Y
Suzuki, M
Tamura, N
Ohwada, M
Sato, I
ONCOLOGY, 2001, 60 (04) : 367 - 372
[3] Establishment and characterization of a cell line (NOMH-1) originating from a human endometrioid adenocarcinoma of the ovary
Takashi Yamada
Takayoshi Kanda
Hiroshi Mori
Kaname Shimokawa
Mitsuo Kagawa
Yuro Shibayama
Journal of Ovarian Research, 6
[4] Establishment and characterization of a cell line (NOMH-1) originating from a human endometrioid adenocarcinoma of the ovary
Yamada, Takashi
Kanda, Takayoshi
Mori, Hiroshi
Shimokawa, Kaname
Kagawa, Mitsuo
Shibayama, Yuro
JOURNAL OF OVARIAN RESEARCH, 2013, 6
[5] Mixed Endometrioid Clear Cell Carcinoma of the Ovary: A Case Report
Hasanzadeh, Malihe
Esmaeilpour, Maryam
Mohammadi, Mahdieh
CURRENT WOMENS HEALTH REVIEWS, 2024, 20 (04) : 63 - 66
[6] Collision Tumor of the Ovary: Adult Granulosa Cell Tumor and Endometrioid Carcinoma
Schoolmeester, J. Kenneth
Keeney, Gary L.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2012, 31 (06) : 538 - 540
[7] Pseudoglandular hepatoid differentiation in endometrioid carcinoma of the ovary simulates oxyphilic cell change
Stolnicu, Simona
Preda, Ovidiu
Dohan, Monica
Puscasiu, Lucian
Garcia-Galvis, Olga F.
Nogales, Francisco F.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2008, 27 (04) : 521 - 525
[8] Association of low-grade endometrioid carcinoma of the uterus and ovary with undifferentiated carcinoma: A new type of dedifferentiated carcinoma?
Silva, EG
Deavers, MT
Bodurka, DC
Malpica, A
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2006, 25 (01) : 52 - 58
[9] ENDOMETRIOID CARCINOMA OF THE OVARY AND ENDOMETRIUM, OXYPHILIC CELL-TYPE - A REPORT OF 9 CASES
PITMAN, MB
YOUNG, RH
CLEMENT, PB
DICKERSIN, GR
SCULLY, RE
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 1994, 13 (04) : 290 - 301
[10] ENDOMETRIOID CARCINOMA OF THE OVARY WITH A PROMINENT SPINDLE-CELL COMPONENT, A SOURCE OF DIAGNOSTIC CONFUSION - A REPORT OF 14 CASES
TORNOS, C
SILVA, EG
ORDONEZ, NG
GERSHENSON, DM
YOUNG, RH
SCULLY, RE
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1995, 19 (12) : 1343 - 1353

← 1 2 3 4 5 →