Met, metastasis, motility and more

被引：2230
作者：
Birchmeier, C
Birchmeier, W
Gherardi, E
Vande Woude, GF
机构：
[1] Van Andel Res Inst, Grand Rapids, MI 49503 USA
[2] Max Delbruck Ctr Mol Med, Dept Neurosci, D-13122 Berlin, Germany
[3] Max Delbruck Ctr Mol Med, Dept Canc Res, D-13122 Berlin, Germany
[4] MRC Ctr, Cambridge CB2 2QH, England
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 12期
关键词：
D O I：
10.1038/nrm1261
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Hepatocyte growth factor/scatter factor and its receptor, the tyrosine kinase Met, arose late in evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1 - homologues of which are present in Caenorhabditis elegans and Drosophila melanogaster for downstream signalling. Pivotal roles for Met in development and cancer have been established: Met controls cell migration and growth in embryogenesis; it also controls growth, invasion and metastasis in cancer cells; and activating Met mutations predispose to human cancer.
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页码：915 / 925
页数：11
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