Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation

被引：53

作者：

Thimmegowda, N. R. ^{[2
]}

Swamy, S. Nanjunda ^{[2
,3
]}

Kumar, C. S. Ananda ^{[2
]}

Kumar, Y. C. Sunil ^{[2
]}

Chandrappa, S. ^{[2
]}

Yip, George W. ^{[1
]}

Rangappa, K. S. ^{[2
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Anat, Singapore 117597, Singapore

[2] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India

[3] Sri Jayachamarajendra Coll Engn, Dept Biotechnol, Mysore 570006, Karnataka, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.bmcl.2007.08.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of trisubstituted benzimidazole and its precursors (3-7) were synthesised and characterized by using H-1 NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed that the compound N-(4-eyano-3-(trifluoromethyl) phenyl)-4-fluoro-3-nitrobenzamide (3) was the potent inhibitor. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：432 / 435

页数：4

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