Prevalence of diphtheria toxin antibodies in human sera from a cross-section of the Italian population

被引：13
作者：
Bergamini, M
Comodo, N
Gasparini, R
Gabutti, G
Fabrizi, P
Severini, R
Ajello, F
Bonanni, P
Catagnari, L
Cocchioni, M
Della Pietra, P
Fragapane, E
Grilli, A
Liberatore, S
Lo Nostro, A
Moiraghi-Ruggenini, A
Pellegrini, MG
Pozzi, T
Tarsitani, G
Zotti, C
Crovari, P
机构：
[1] Univ Ferrara, Dept Clin & Expt Med, I-44100 Ferrara, Italy
[2] Univ Florence, Dept Epidemiol & Publ Hlth, I-50134 Florence, Italy
[3] Univ Siena, Inst Hyg, I-53100 Siena, Italy
[4] Univ Genoa, Inst Hyg & Prevent Med, I-16132 Genoa, Italy
[5] Sclavo Diagnost, I-53100 Siena, Italy
[6] Sclavo Spa, I-53100 Siena, Italy
[7] Univ Palermo, Dept Hyg & Microbiol GD Allessandro, I-90127 Palermo, Italy
[8] Univ Camerino, Dept Environm & Sanit Hyg, I-62032 Camerino, Italy
[9] Univ Aquila, Dept Cellular Biol & Physiol, I-67100 Laquila, Italy
[10] Univ Turin, Dept Publ Hlth & Microbiol, I-10126 Turin, Italy
来源：
VACCINE | 1999年 / 17卷 / 03期
关键词：
diphtheria; diphtheria antitoxin; cross-sectional studies; immunoenzyme techniques; adults; Italy;
D O I：
10.1016/S0264-410X(98)00053-X
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A polycentric study was carried out between 1993 and 1995 in order to evaluate diphtheria immunity on a representative sample of population from different areas of Italy. To determine diphtheria antitoxin, sera from 5187 apparently healthy subjects, divided according to sex and age groups, were titrated using an ELISA indirect method. A basic protective titre of diphtheria antitoxin (> 0.01 IU ml(-1)) was found in 4050 (78.6%) subjects. No statistically significant differences between males and females were observed. Our findings show that the proportion of susceptibles increases with age and a high proportion of adults no longer has diphtheria antitoxin at protective levels since toxigenic C. diphtheriae circulation is presently lacking in Italy. (C) 1998 Elsevier Science Ltd. All rights reserved.
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收藏
页码：286 / 290
页数：5
相关论文
共 26 条
[1]   SEROCONVERSION IN JUVENILE PATIENTS AND ADULTS AFTER DIPHTHERIA IMMUNIZATION - A STUDY OF THE HAMBURG HOSPITAL PERSONNEL [J].
ALLERDIST, H ;
EHRENGUTLANGE, J .
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1982, 107 (46) :1755-1760
[2]  
Bergamini Mauro, 1993, Igiene Moderna, V100, P484
[3]   ANTITOXIN ANTIBODY-LEVELS AND THE OUTCOME OF ILLNESS DURING AN OUTBREAK OF DIPHTHERIA AMONG ALCOHOLICS [J].
BJORKHOLM, B ;
BOTTIGER, M ;
CHRISTENSON, B ;
HAGBERG, L .
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1986, 18 (03) :235-239
[4]   IMMUNITY TO DIPHTHERIA IN A SAMPLE OF ADULT-POPULATION FROM CENTRAL ITALY [J].
CELLESI, C ;
ZANCHI, A ;
MICHELANGELI, C ;
GIOVANNONI, F ;
SANSONI, A ;
ROSSOLINI, GM .
VACCINE, 1989, 7 (05) :417-420
[5]   IMMUNITY TO DIPHTHERIA IN THE 3-19 YEAR AGE GROUP IN ITALY [J].
CHIARINI, A ;
GIAMMANCO, A ;
STROFFOLINI, T ;
DEMATTIA, D ;
MASIA, MD ;
SARZANA, A ;
TAORMINA, S ;
MAGGIO, M ;
RIGO, G ;
CHIARAMONTE, M ;
TRIVELLO, R ;
SCARPA, B .
VACCINE, 1991, 9 (11) :837-839
[6]   Low prevalence of diphtheria immunity in the population of Florence, Italy [J].
Comodo, N ;
Bonanni, P ;
LoNostro, A ;
Tiscione, E ;
Mannelli, F ;
Tomei, A .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 1996, 12 (03) :251-255
[7]   RESURGENCE OF DIPHTHERIA [J].
GALAZKA, AM ;
ROBERTSON, SE ;
OBLAPENKO, GP .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 1995, 11 (01) :95-105
[8]   Immunity to diphtheria in Siena [J].
Gasparini, R ;
Pozzi, T ;
Fragapane, E ;
Severini, R ;
Cellesi, C ;
Fabrizi, P ;
Provvedi, A ;
Bergamini, M .
EPIDEMIOLOGY AND INFECTION, 1997, 119 (02) :203-208
[9]  
GROSS R, 1991, VACCINES IMMUNOTHERA, P1
[10]  
*ISTAT, 1939, ANN STAT IT
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