Exploring the role of cathepsin in rheumatoid arthritis

被引：46

作者：

Behl, Tapan ^{[1
]}

Chadha, Swati ^{[1
]}

Sehgal, Aayush ^{[1
]}

Singh, Sukhbir ^{[1
]}

Sharma, Neelam ^{[1
]}

Kaur, Rajwinder ^{[1
]}

Bhatia, Saurabh ^{[2
,3
]}

Al-Harrasi, Ahmed ^{[2
]}

Chigurupati, Sridevi ^{[4
]}

Alhowail, Ahmed ^{[5
]}

Bungau, Simona ^{[6
]}

机构：

[1] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India

[2] Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa, Oman

[3] Amity Univ, Amity Inst Pharm, Panchgaon, Haryana, India

[4] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Buraydah, Saudi Arabia

[5] Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Buraydah, Saudi Arabia

[6] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea, Romania

来源：

SAUDI JOURNAL OF BIOLOGICAL SCIENCES | 2022年 / 29卷 / 01期

关键词：

Cathepsin; Inflammation; Rheumatoid arthritis; Cysteine protease; Matrix-metalloprotease; CYSTATIN-C; COLLAGENOLYTIC ACTIVITY; NEUTROPHIL ELASTASE; CYSTEINE CATHEPSINS; ARTICULAR-CARTILAGE; BONE-RESORPTION; SYNOVIAL-FLUID; K INHIBITORS; S INHIBITORS; PROTEASES;

D O I：

10.1016/j.sjbs.2021.09.014

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rheumatoid arthritis (RA) is a chronic inflammatory disease which is marked by leukocytes infiltration inside synovial tissue, joints and also inside synovial fluid which causes progressive destruction of joint cartilage. There are numerous genetical and lifestyle factors, responsible for rheumatoid arthritis. One such factor can be cysteine cathepsins, which act as proteolytic enzymes. These proteolytic enzyme gets activated at acidic pH and are found in lysosomes and are also termed as cysteine proteases. These proteases belong to papain family and have their elucidated role in musculoskeletal disorders. Numerous cathepsins have their targeted role in rheumatoid arthritis. These proteases are secreted through various cell types which includes matrix metalloproteases and papain like cysteine proteases. These proteases can potentially lead to bone and cartilage destruction which causes an immune response in case of inflammatory arthritis. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

引用

页码：402 / 410

页数：9

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