Epigenetics: How does obesity lead to insulin resistance?

被引:14
作者
Choi, Chan Hee J. [1 ]
Cohen, Paul [1 ]
机构
[1] Rockefeller Univ, Lab Mol Metab, New York, NY 10065 USA
关键词
MECHANISMS;
D O I
10.7554/eLife.33298
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页数:2
相关论文
共 10 条
[1]   Regulation of mammalian DNA methyltransferases: a route to new mechanisms [J].
Denis, Helene ;
Ndlovu, Matladi N. ;
Fuks, Francois .
EMBO REPORTS, 2011, 12 (07) :647-656
[2]   Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals [J].
Jaenisch, R ;
Bird, A .
NATURE GENETICS, 2003, 33 (Suppl 3) :245-254
[3]   Obesity and insulin resistance [J].
Kahn, BB ;
Flier, JS .
JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (04) :473-481
[4]   FGF-21 as a novel metabolic regulator [J].
Kharitonenkov, A ;
Shiyanova, TL ;
Koester, A ;
Ford, AM ;
Micanovic, R ;
Galbreath, EJ ;
Sandusky, GE ;
Hammond, LJ ;
Moyers, JS ;
Owens, RA ;
Gromada, J ;
Brozinick, JT ;
Hawkins, ED ;
Wroblewski, VJ ;
Li, DS ;
Mehrbod, F ;
Jaskunas, SR ;
Shanafelt, AB .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (06) :1627-1635
[5]   Islet β cell failure in type 2 diabetes [J].
Prentki, Marc ;
Nolan, Christopher J. .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (07) :1802-1812
[6]   Insulin signalling and the regulation of glucose and lipid metabolism [J].
Saltiel, AR ;
Kahn, CR .
NATURE, 2001, 414 (6865) :799-806
[7]   Mechanisms for Insulin Resistance: Common Threads and Missing Links [J].
Samuel, Varman T. ;
Shulman, Gerald I. .
CELL, 2012, 148 (05) :852-871
[8]   Critical nodes in signalling pathways: insights into insulin action [J].
Taniguchi, CM ;
Emanuelli, B ;
Kahn, CR .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (02) :85-96
[9]   Drug therapy: Thiazolidinediones [J].
Yki-Jarvinen, H .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (11) :1106-1118
[10]   Dnmt3a is an epigenetic mediator of adipose insulin resistance [J].
You, Dongjoo ;
Nilsson, Emma ;
Tenen, Danielle E. ;
Lyubetskaya, Anna ;
Lo, James C. ;
Jiang, Rencong ;
Deng, Jasmine ;
Dawes, Brian A. ;
Vaag, Allan ;
Ling, Charlotte ;
Rosen, Evan D. ;
Kang, Sona .
ELIFE, 2017, 6