Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

被引：156

作者：

Ross, Owen A. ^{[1
]}

Wu, Yih-Ru ^{[2
,3
]}

Lee, Mei-Ching ^{[4
]}

Funayama, Manabu ^{[5
]}

Chen, Meng-Ling ^{[6
]}

Soto, Alexandra I. ^{[1
]}

Mata, Ignacio F. ^{[7
]}

Lee-Chen, Guey-Jen ^{[8
]}

Chen, Chiung Mei ^{[2
,3
]}

Tang, Michelle ^{[9
]}

Zhao, Yi ^{[9
]}

Hattori, Nobutaka ^{[5
,10
]}

Farrer, Matthew J. ^{[1
]}

Tan, Eng-King ^{[9
,11
]}

Wu, Ruey-Meei ^{[6
]}

机构：

[1] Mayo Clin, Coll Med, Dept Neurosci, Jacksonville, FL 32224 USA

[2] Chang Gung Mem Hosp, Dept Neurol, Taipei 10591, Taiwan

[3] Chang Gung Univ, Coll Med, Taipei, Taiwan

[4] Cathay Gen Hosp, Dept Neurol, Taipei, Taiwan

[5] Juntendo Univ, Sch Med, Res Inst Dis Old Ages, Bunkyo Ku, Tokyo 113, Japan

[6] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Neurol, Taipei, Taiwan

[7] Univ Washington, Sch Med, Dept Neurol, Seattle, WA USA

[8] Natl Taiwan Normal Univ, Dept Life Sci, Taipei, Taiwan

[9] Singapore Gen Hosp, Dept Neurol, Natl Neurosci Inst Singapore, Singapore, Singapore

[10] Juntendo Univ, Sch Med, Dept Neurol, Bunkyo Ku, Tokyo 113, Japan

[11] Duke NUS Grad Med Sch, Singapore, Singapore

来源：

ANNALS OF NEUROLOGY | 2008年 / 64卷 / 01期

关键词：

D O I：

10.1002/ana.21405

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G > C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; P = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LRRK2 variants in sporadic Parkinson's disease.

引用

页码：88 / 92

页数：5

共 15 条

[1] LRRK2 Gly2385Arg variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China [J].

An, X. -K. ;

Peng, R. ;

Li, T. ;

Burgunder, J. -M. ;

Wu, Y. ;

Chen, W. -J. ;

Zhang, J. -H. ;

Wang, Y. -C. ;

Xu, Y. -M. ;

Gou, Y. -R. ;

Yuan, G. -G. ;

Zhang, Z. -J. .

EUROPEAN JOURNAL OF NEUROLOGY, 2008, 15 (03) :301-305

[2] The western Swedish BRCA1 founder mutation 3171ins5;: a 3.7 cM conserved haplotype of today is a reminiscence of a 1500-year-old mutation [J].

Bergman, A ;

Einbeigi, Z ;

Olofsson, U ;

Taib, Z ;

Wallgren, A ;

Karlsson, P ;

Wahlström, J ;

Martinsson, T ;

Nordling, M .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2001, 9 (10) :787-793

[3] Common variants of LRRK2 are not associated with sporadic Parkinson's disease [J].

Biskup, S ;

Mueller, JC ;

Sharma, M ;

Lichtner, P ;

Zimprich, A ;

Berg, D ;

Wüllner, U ;

Illig, T ;

Meitinger, T ;

Gasser, T .

ANNALS OF NEUROLOGY, 2005, 58 (06) :905-908

[4] A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan [J].

Di Fonzo, Alessio ;

Wu-Chou, Yah-Huei ;

Lu, Chin-Song ;

van Doeselaar, Marina ;

Simons, Erik J. ;

Rohe, Christan F. ;

Chang, Hsiu-Chen ;

Chen, Rou-Shayn ;

Weng, Yi-Hsin ;

Vanacore, Nicola ;

Breedveld, Guido J. ;

Oostra, Ben A. ;

Bonifati, Vincenzo .

NEUROGENETICS, 2006, 7 (03) :133-138

[5] Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia [J].

Farrer, Matthew J. ;

Stone, Jeremy T. ;

Lin, Chin-Hsien ;

Dachsel, Justus C. ;

Hulihan, Mary M. ;

Haugarvoll, Kristoffer ;

Ross, Owen A. ;

Wu, Ruey-Meei .

PARKINSONISM & RELATED DISORDERS, 2007, 13 (02) :89-92

[6] Leucine-Rich Repeat kinase 2 G238SR variant is a risk factor for Parkinson disease in Asian population [J].

Funayama, Manabu ;

Li, Yuanzhe ;

Tomiyama, Hiroyuki ;

Yoshino, Hiroyo ;

Imamichi, Yoko ;

Yamamoto, Mitsutoshi ;

Murata, Miho ;

Toda, Tatsushi ;

Mizuno, Yoshikuni ;

Hattori, Nobutaka .

NEUROREPORT, 2007, 18 (03) :273-275

[7] A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan [J].

Fung, Hon-Chung ;

Chen, Chiung-Mei ;

Hardy, John ;

Singleton, Andrew B. ;

Wu, Yih-Ru .

BMC NEUROLOGY, 2006, 6 (1)

[8] Diagnostic criteria for Parkinson disease [J].

Gelb, DJ ;

Oliver, E ;

Gilman, S .

ARCHIVES OF NEUROLOGY, 1999, 56 (01) :33-39

[9] Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations [J].

Ishihara, Lianna ;

Warren, Liling ;

Gibson, Rachel ;

Amouri, Rim ;

Lesage, Suzanne ;

Durr, Alexandra ;

Tazir, Meriem ;

Wszolek, Zbigniew K. ;

Uitti, Ryan J. ;

Nichols, William C. ;

Griffith, Alida ;

Hattori, Nobutaka ;

Leppert, David ;

Watts, Ray ;

Zabetian, Cyrus P. ;

Foroud, Tatiana M. ;

Farrer, Matthew J. ;

Brice, Alexis ;

Middleton, Lefkos ;

Hentati, Faycal .

ARCHIVES OF NEUROLOGY, 2006, 63 (09) :1250-1254

[10] The prevalence of LRRK2 Gly2385Arg variant in Chinese Han population with Parkinson's disease [J].

Li, Cao ;

Ting, Zhang ;

Qin, Xiao ;

Ying, Wang ;

Li, Bai ;

Qiang, Lu Guo ;

Fang, Ma Jian ;

Jing, Zhang ;

Qing, Ding Jian ;

Di, Chen Sheng .

MOVEMENT DISORDERS, 2007, 22 (16) :2439-2443

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