Calix[4]arene based 1,3,4-oxadiazole and thiadiazole derivatives: Design, synthesis, and biological evaluation

被引：48

作者：

Patel, Manishkumar B. ^{[1
]}

Modi, Nishith R. ^{[1
]}

Raval, Jignesh P. ^{[2
]}

Menon, Shobhana K. ^{[1
]}

机构：

[1] Gujarat Univ, Sch Sci, Dept Chem, Ahmadabad 380009, Gujarat, India

[2] Ashok & Rita Patel Inst Integrated Study & Res Bi, Dept Pharmaceut Chem, New Vallabh Vidyanagar 388121, Gujarat, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 09期

关键词：

ANTIMYCOBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; IN-VITRO; CALIXARENES; ANTIBACTERIAL; GUANIDINIUM; LIPOPHILICITY; BACTERIA; SERIES;

D O I：

10.1039/c2ob06730g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the present investigation, we describe some novel calixarene based heterocyclic compounds (5a-5i) in which 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives have been coupled with 5,11,17,23-tetra-tertbutyl-25,27-bis(chlorocarbonyl-methoxy)-26,28-dihydroxy calix[4]arene. All the newly synthesized calixarene based heterocyclic compounds have been characterized by elemental analysis and various spectroscopic methods like FTIR, H-1 NMR, C-13 NMR, and FAB-MS. All the final scaffolds have been subjected to antioxidant activity, in vitro antimicrobial screening against two gram (+ve) bacteria (S. aureus, S. pyogenes), two gram (-ve) bacteria (E. coli, P. aeruginosa) and two fungal strains (C. albicans, A. clavatus) and also have been screened for their antitubercular activity against Mycobacterium tuberculosis H(37)Rv.

引用

页码：1785 / 1794

页数：10

共 57 条

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